Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.69 |
| ▸ | HTT | P42858 | 3/20 | 0.69 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.69 |
| ▸ | NPC1 | O15118 | 1/20 | 0.65 |
| ▸ | TSHR | P16473 | 1/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.63 |
| ▸ | GLA | P06280 | 1/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.63 |
| ▸ | PKM | P14618 | 1/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.63 |
| ▸ | RECQL | P46063 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
| ▸ | TP53 | P04637 | 3/20 | 0.62 |
| ▸ | ALPL | P05186 | 3/20 | 0.62 |
| ▸ | HPGD | P15428 | 2/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22095987 | 0.92 | SMN1; SMN2 (0.78) | LMNASMN1; SMN2HTTNPSR1NPC1 | |
| SCHEMBL95201 | 0.86 | NPSR1 (0.69) | LMNASMN1; SMN2HTTNPSR1NPC1 | |
| SCHEMBL7578214 | 0.86 | USP2 (0.73) | LMNASMN1; SMN2HTTNPSR1NPC1 | |
| SCHEMBL7536903 | 0.84 | LMNA (0.75) | LMNASMN1; SMN2HTTNPSR1MEN1 | |
| SCHEMBL7587628 | 0.84 | NPC1 (0.70) | LMNASMN1; SMN2HTTNPSR1NPC1 | |
| SCHEMBL15211844 | 0.84 | ALPL (0.87) | ALPL | |
| SCHEMBL23846500 | 0.83 | LMNA (0.73) | LMNASMN1; SMN2HTTMEN1ALDH1A1 | |
| SCHEMBL21761109 | 0.83 | LMNA (0.73) | LMNASMN1; SMN2HTTMEN1ALDH1A1 | |
| SCHEMBL12971600 | 0.83 | USP2 (0.76) | LMNASMN1; SMN2HTTNPSR1ALPL | |
| SCHEMBL7529463 | 0.82 | TP53 (0.80) | LMNASMN1; SMN2HTTNPSR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1239852-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | Arrow Therapeutics Limited (GB) | 2002-09-18 | — | — | EP | disclosed |
| WO-2001028537-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | ARROW THERAPEUTICS LIMITED (GB) | 2001-04-26 | — | — | WO | disclosed |