Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 3/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.33 |
| ▸ | LPAR1 | Q92633 | 3/20 | 0.33 |
| ▸ | LPAR5 | Q9H1C0 | 3/20 | 0.33 |
| ▸ | LTA4H | P09960 | 1/20 | 0.32 |
| ▸ | GHSR | Q92847 | 3/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7557647 | 0.93 | PTPN1 (0.37) | PTPN1GHSRMEN1HTTKMT2A | |
| SCHEMBL5810842 | 0.79 | RAB9A (0.51) | PTPN1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL5810837 | 0.79 | RAB9A (0.51) | PTPN1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL5837749 | 0.76 | PTPN1 (0.48) | PTPN1 | |
| SCHEMBL7096351 | 0.73 | KDM4E (0.43) | PTPN1MEN1KMT2A | |
| SCHEMBL5794533 | 0.72 | PTPN1 (0.40) | PTPN1MEN1MAPTHTTKMT2A | |
| SCHEMBL7578658 | 0.70 | HPGD (0.36) | PTPN1MEN1MAPTHTTKMT2A | |
| SCHEMBL5773123 | 0.69 | PTPN1 (0.58) | PTPN1P2RX7MEN1MAPTHTT | |
| SCHEMBL7540101 | 0.69 | PTPN1 (0.31) | PTPN1 | |
| SCHEMBL7572308 | 0.68 | PTPN1 (0.35) | PTPN1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1214060-A2 | METHOD OF INHIBITING PROTEIN TYROSINE PHOSPHATASE 1B AND/OR T-CELL PROTEIN TYROSINE PHOSPHATASE AND/OR OTHER PTPASES WITH AN ASP RESIDUE AT POSITION 48 | NOVO NORDISK A/S (DK) | 2002-06-19 | — | — | EP | claimed |
| WO-2001017516-A2 | METHOD OF INHIBITING PROTEIN TYROSINE PHOSPHATASE 1B AND/OR T-CELL PROTEIN TYROSINE PHOSPHATASE AND/OR OTHER PTPASES WITH AN ASP RESIDUE AT POSITION 48 | NOVO NORDISK A/S (DK) | 2001-03-15 | — | — | WO | claimed |