Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.36 |
| ▸ | POLB | P06746 | 4/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.34 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.34 |
| ▸ | PTPRB | P23467 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7540101 | 0.83 | PTPN1 (0.31) | PTPN1PTPN2 | |
| SCHEMBL7508290 | 0.80 | PTPN1 (0.47) | PTPN1PTPN2PTPRB | |
| SCHEMBL5838584 | 0.80 | PTPN1 (0.47) | PTPN1PTPN2PTPRB | |
| SCHEMBL7095258 | 0.74 | POLB (0.45) | HPGDPOLBPTPN1LMNASMN1; SMN2 | |
| SCHEMBL7096724 | 0.72 | PTPN1 (0.58) | HPGDRAB9ANPC1PTPN1ALDH1A1 | |
| SCHEMBL7096725 | 0.72 | PTPN1 (0.58) | HPGDRAB9ANPC1PTPN1ALDH1A1 | |
| SCHEMBL5810837 | 0.72 | RAB9A (0.51) | HPGDRAB9ANPC1PTPN1LMNA | |
| SCHEMBL5810842 | 0.72 | RAB9A (0.51) | HPGDRAB9ANPC1PTPN1LMNA | |
| SCHEMBL7091991 | 0.72 | PTPN1 (0.42) | HPGDRAB9ANPC1PTPN1MAPT | |
| SCHEMBL7537220 | 0.70 | PTPN1 (0.37) | PTPN1MAPTSMN1; SMN2HTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1214324-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK A/S (DK) | 2002-06-19 | — | — | EP | claimed |
| WO-2001019830-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK A/S (DK) | 2001-03-22 | — | — | WO | claimed |