SCHEMBL7537589

SCHEMBL7537589

CC(C)c1ccc(S(=O)(=O)Nc2ccsc2C(=O)Nc2cccc(Cl)c2)cc1.Cc1ccc(S(=O)(=O)Nc2ccsc2C(=O)Nc2cccc(Cl)c2)cc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTT P42858 4/20 0.49
CYP1A2 P05177 3/20 0.49
CYP3A4 P08684 3/20 0.49
CYP2D6 P10635 3/20 0.49
CYP2C9 P11712 3/20 0.49
CYP2C19 P33261 3/20 0.49
L3MBTL1 Q9Y468 2/20 0.49
MAPT P10636 10/20 0.46
MEN1 O00255 7/20 0.46
KMT2A Q03164 7/20 0.46
GAA P10253 2/20 0.46
RECQL P46063 1/20 0.46
PGR P06401 1/20 0.46
LMNA P02545 3/20 0.45
GPR27 Q9NS67 2/20 0.45
ALDH1A1 P00352 2/20 0.44
SMN1; SMN2 Q16637 2/20 0.44
CCR2 P41597 1/20 0.44
MAPK1 P28482 2/20 0.44
ACLY P53396 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7533623 0.85 ACLY (0.55) HTTCYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL7532028 0.84 ADORA3 (0.53) HTTCYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL7534436 0.84 LMNA (0.60) HTTCYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL7533934 0.84 HTT (0.52) HTTCYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL7534376 0.84 L3MBTL1 (0.52) HTTCYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL7531711 0.83 CYP1A2 (0.52) HTTCYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL7531361 0.83 L3MBTL1 (0.53) HTTCYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL7533516 0.82 HTT (0.50) HTTCYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL7533670 0.82 HTT (0.52) HTTCYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL7533559 0.82 HTT (0.49) HTTCYP1A2CYP3A4CYP2D6CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2002028353-A2 PHOSPHATE TRANSPORT INHIBITORS SMITHKLINE BEECHAM CORPORATION (US) 2002-04-11 WO claimed
WO-2002028353-A2 PHOSPHATE TRANSPORT INHIBITORS SMITHKLINE BEECHAM CORPORATION (US) 2002-04-11 WO disclosed