Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.71 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.68 |
| ▸ | USP2 | O75604 | 1/20 | 0.68 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | HTR3A | P46098 | 1/20 | 0.58 |
| ▸ | DRD2 | P14416 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7545873 | 0.94 | L3MBTL1 (0.65) | LMNAL3MBTL1KMT2AUSP2OPRK1 | |
| SCHEMBL22582589 | 0.89 | LMNA (0.74) | LMNAL3MBTL1KMT2AUSP2OPRK1 | |
| SCHEMBL12479774 | 0.89 | LMNA (0.74) | LMNAL3MBTL1KMT2AUSP2OPRK1 | |
| SCHEMBL22582588 | 0.89 | LMNA (0.74) | LMNAL3MBTL1KMT2AUSP2OPRK1 | |
| SCHEMBL22582593 | 0.89 | LMNA (0.74) | LMNAL3MBTL1KMT2AUSP2OPRK1 | |
| SCHEMBL10812960 | 0.86 | KMT2A (0.72) | LMNAL3MBTL1KMT2AUSP2OPRK1 | |
| SCHEMBL22582542 | 0.83 | KMT2A (0.67) | LMNAL3MBTL1KMT2AUSP2OPRK1 | |
| SCHEMBL22582544 | 0.83 | KMT2A (0.67) | LMNAL3MBTL1KMT2AUSP2OPRK1 | |
| SCHEMBL22582539 | 0.83 | KMT2A (0.67) | LMNAL3MBTL1KMT2AUSP2OPRK1 | |
| SCHEMBL4274767 | 0.83 | L3MBTL1 (0.68) | LMNAL3MBTL1KMT2AUSP2OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1254123-A1 | 2-BENZOTHIAZOLYL UREA DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | Abbott GmbH & Co. KG (DE) | 2002-11-06 | — | — | EP | disclosed |
| WO-2001057008-A1 | 2-BENZOTHIAZOLYL UREA DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | ABBOTT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG & COMPANY KOMMANDITGESELLSCHAFT (DE) | 2001-08-09 | — | — | WO | disclosed |