SCHEMBL753849

SCHEMBL753849

O=S(=O)(C(I)(I)c1ccccc1)C(I)(I)c1ccccc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 2/20 0.43
CA2 P00918 2/20 0.43
CA5A P35218 2/20 0.43
CA9 Q16790 2/20 0.43
TSHR P16473 3/20 0.38
ALDH1A1 P00352 2/20 0.38
KCNN4 O15554 2/20 0.38
HTR6 P50406 1/20 0.38
CYP1A2 P05177 1/20 0.36
NR3C2 P08235 3/20 0.35
MEN1 O00255 1/20 0.35
CDC25B P30305 1/20 0.35
KMT2A Q03164 1/20 0.35
HSD17B10 Q99714 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
CA12 O43570 1/20 0.35
CA3 P07451 1/20 0.35
CA4 P22748 1/20 0.35
CA6 P23280 1/20 0.35
CA7 P43166 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL753958 0.75 TSHR (0.42) CA1CA2CA5ACA9TSHR
SCHEMBL754508 0.75 CA2 (0.47) CA1CA2CA5ACA9CA12
SCHEMBL751562 0.75 ALDH1A1 (0.50) CA1CA2CA9TSHRALDH1A1
SCHEMBL752253 0.73 ACHE (0.42) TSHRALDH1A1KMT2ATDP1L3MBTL1
SCHEMBL8138277 0.72 CA1 (0.46) CA1CA2CA5ACA9TSHR
SCHEMBL6743173 0.70 CA1 (0.44) CA1CA2CA5ACA9TSHR
SCHEMBL778852 0.68 MAPK1 (0.44) CA1CA2CA5ACA9ALDH1A1
SCHEMBL5871749 0.68 TSHR (0.50) CA1CA2CA5ACA9TSHR
SCHEMBL4124865 0.68 CA1 (0.67) CA1CA2CA5ACA9TSHR
SCHEMBL2261820 0.67 KCNN4 (0.47) CA1CA2CA5ACA9TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2213166-B1 Biocidal compounds containing 2-methylisothiazolin-3-one and a haloalkylsulfone THOR GMBH (DE) 2012-03-21 EP claimed
US-5773157-A SUBSTRATE WITH MAGNETIC COATING LAYER OF POWDERS AND BINDERS TEIJIN LIMITED (JP) 1998-06-30 US disclosed
EP-0640959-B1 Magnetic recording medium with fungiresistance and process for manufacturing same TEIJIN LTD (JP) 1998-01-07 EP disclosed
EP-0640959-A1 Magnetic recording medium with fungiresistance and process for manufacturing same TEIJIN LIMITED (JP) 1995-03-01 EP disclosed
US-4018611-A Non-yellowing antimicrobial compositions comprising diiodomethyl sulfones METALORGANA ETABLISSEMENT (FL) 1977-04-19 US disclosed