Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | INMT | O95050 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SCN1A | P35498 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3864473 | 0.81 | ALDH1A1 (0.45) | SIGMAR1MEN1NPC1RAB9AKMT2A | |
| Hydrochloric Acid SCHEMBL5631058 | 0.79 | ALDH1A1 (0.48) | SIGMAR1MEN1NPC1RAB9AKMT2A | |
| Hydrochloric Acid SCHEMBL11721493 | 0.78 | RAB9A (0.43) | SIGMAR1RAB9AALOX5KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL6771290 | 0.77 | ALDH1A1 (0.65) | MEN1NPC1RAB9AKMT2AKDM4E | |
| SCHEMBL14199843 | 0.77 | SIGMAR1 (0.82) | SIGMAR1MEN1NPC1RAB9AKMT2A | |
| SCHEMBL4426213 | 0.76 | SIGMAR1 (0.46) | SIGMAR1MEN1NPC1RAB9AKMT2A | |
| SCHEMBL6140774 | 0.75 | KMT2A (0.43) | MEN1NPC1RAB9AKMT2AALDH1A1 | |
| SCHEMBL3868815 | 0.75 | ALDH1A1 (0.48) | SIGMAR1MEN1NPC1RAB9AKMT2A | |
| SCHEMBL21507867 | 0.74 | SIGMAR1 (0.45) | SIGMAR1MEN1NPC1RAB9AKMT2A | |
| SCHEMBL29052583 | 0.74 | SIGMAR1 (0.45) | SIGMAR1MEN1NPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934265-A1 | AMIDINOPHENYL-PYRROLIDINES, -PYRROLINES, AND -ISOXAZOLIDINES AND DERIVATIVES THEREOF | Du Pont Pharmaceuticals Company (US) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998006694-A1 | AMIDINOPHENYL-PYRROLIDINES, -PYRROLINES, AND -ISOXAZOLIDINES AND DERIVATIVES THEREOF | DU PONT PHARMACEUTICALS COMPANY (US) | 1998-02-19 | — | — | WO | disclosed |
| US-4052382-A | 1-PHENYL-3-AZACARBOCYCLIC-UREAS | STERLING DRUG INC. (US) | 1977-10-04 | — | — | US | disclosed |
| US-4026938-A | 1-Phenyl-3-azacarbocyclic-ureas | STERLING DRUG INC. (US) | 1977-05-31 | — | — | US | disclosed |
| US-3963748-A | 1-Phenyl-3-azacarbocyclic-ureas | STERLING DRUG INC. (US) | 1976-06-15 | — | — | US | disclosed |