Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 15/20 | 0.44 |
| ▸ | MMP13 | P45452 | 13/20 | 0.44 |
| ▸ | MMP1 | P03956 | 11/20 | 0.44 |
| ▸ | ADAM17 | P78536 | 8/20 | 0.44 |
| ▸ | MMP2 | P08253 | 9/20 | 0.41 |
| ▸ | MMP8 | P22894 | 6/20 | 0.41 |
| ▸ | MMP3 | P08254 | 5/20 | 0.41 |
| ▸ | MMP14 | P50281 | 4/20 | 0.41 |
| ▸ | MMP16 | P51512 | 3/20 | 0.41 |
| ▸ | DUT | P33316 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | BMP1 | P13497 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7533819 | 1.00 | MMP9 (0.44) | MMP9MMP13MMP1ADAM17MMP2 | |
| SCHEMBL7532942 | 0.92 | MMP9 (0.44) | MMP9MMP13MMP1ADAM17MMP2 | |
| SCHEMBL7532945 | 0.92 | MMP9 (0.44) | MMP9MMP13MMP1ADAM17MMP2 | |
| SCHEMBL7533025 | 0.86 | MMP9 (0.44) | MMP9MMP13MMP1ADAM17MMP2 | |
| SCHEMBL7533029 | 0.86 | MMP9 (0.44) | MMP9MMP13MMP1ADAM17MMP2 | |
| SCHEMBL7532363 | 0.84 | MMP13 (0.51) | MMP9MMP13MMP1ADAM17MMP2 | |
| SCHEMBL7532360 | 0.84 | MMP13 (0.51) | MMP9MMP13MMP1ADAM17MMP2 | |
| SCHEMBL7539814 | 0.83 | MMP1 (0.46) | MMP9MMP13MMP1ADAM17MMP2 | |
| SCHEMBL7539821 | 0.83 | MMP1 (0.46) | MMP9MMP13MMP1ADAM17MMP2 | |
| SCHEMBL7536288 | 0.80 | BMP1 (0.51) | MMP9MMP13MMP1ADAM17MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0951466-A2 | CYCLOALKYL, LACTAM, LACTONE AND RELATED COMPOUNDS, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, AND METHODS FOR INHIBITING BETA-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS BY USE OF SUCH COMPOUNDS | Elan Pharmaceuticals, Inc. (US) | 1999-10-27 | — | — | EP | disclosed |
| WO-1998028268-A2 | CYCLOALKYL, LACTAM, LACTONE AND RELATED COMPOUNDS AS β-AMYLOID PEPTIDE RELEASE INHIBITORS | ELAN PHARMACEUTICALS, INC. (US) | 1998-07-02 | — | — | WO | disclosed |