Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 5/20 | 0.61 |
| ▸ | ADRB1 known ✓ | P08588 | 4/20 | 0.61 |
| ▸ | ADRB3 | P13945 | 16/20 | 0.60 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5462807 | 0.96 | ADRB2 (0.65) | ADRB2ADRB1ADRB3DNM1LMNA | |
| Hydrochloric Acid SCHEMBL5831847 | 0.95 | ADRB3 (0.66) | ADRB2ADRB1ADRB3DNM1LMNA | |
| Malonic Acid SCHEMBL7535091 | 0.94 | ADRB2 (0.64) | ADRB2ADRB1ADRB3DNM1LMNA | |
| Sulfuric Acid SCHEMBL7535094 | 0.93 | ADRB2 (0.62) | ADRB2ADRB1ADRB3DNM1MAPT | |
| Phosphoric Acid SCHEMBL7535040 | 0.93 | ADRB2 (0.62) | ADRB2ADRB1ADRB3DNM1MAPT | |
| Glutarate SCHEMBL7534559 | 0.92 | ADRB2 (0.64) | ADRB2ADRB1ADRB3DNM1LMNA | |
| SCHEMBL5471218 | 0.91 | ADRB2 (0.56) | ADRB2ADRB1ADRB3DNM1LMNA | |
| SCHEMBL5830787 | 0.88 | ADRB2 (0.53) | ADRB2ADRB1ADRB3DNM1LMNA | |
| Hydrochloric Acid SCHEMBL5831925 | 0.87 | ADRB3 (0.54) | ADRB2ADRB1ADRB3DNM1LMNA | |
| SCHEMBL5830214 | 0.87 | ADRB1 (0.54) | ADRB2ADRB1ADRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020165234-A1 | Selective B3 adrenergic agonists | CROWELL THOMAS A (US) | 2002-11-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020165234-A1 | Selective B3 adrenergic agonists | ADRB3, ADRB2, ADRB1 | ADRB2 2/4885ADRB1 3/4885ADRB3 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.