Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TK1 | P04183 | 3/20 | 0.37 |
| ▸ | TYMP | P19971 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | CA7 | P43166 | 2/20 | 0.33 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CA4 | P22748 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8584030 | 0.82 | SQOR (0.38) | TK1 | |
| SCHEMBL7535820 | 0.79 | MAOA (0.39) | TK1 | |
| SCHEMBL7535823 | 0.73 | TK1 (0.35) | TK1TYMPMAPK1 | |
| SCHEMBL7535814 | 0.73 | TK1 (0.35) | TK1TYMPMAPK1 | |
| SCHEMBL16653120 | 0.72 | TK1 (0.43) | TK1TYMPMAPK1 | |
| SCHEMBL7197137 | 0.69 | MEN1 (0.46) | — | |
| SCHEMBL27811029 | 0.68 | PPARA (0.47) | — | |
| SCHEMBL8646265 | 0.68 | CYP2D6 (0.51) | CA1CA2CA7 | |
| SCHEMBL2166916 | 0.68 | CA1 (0.49) | CA1CA2CA7 | |
| SCHEMBL2685934 | 0.68 | TK1 (0.37) | TK1TYMP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0734391-B1 | PNA-DNA-PNA CHIMERIC MACROMOLECULES | ISIS PHARMACEUTICALS INC (US) | 2002-06-12 | — | — | EP | disclosed |
| EP-1201676-A2 | PNA-DNA-PNA chimeric macromolecules | ISIS PHARMACEUTICALS, INC. (US) | 2002-05-02 | — | — | EP | disclosed |
| US-6277603-B1 | PEPTIDE NUCLEIC ACID (PNA); THE DNA PORTION IS COMPOSED OF SUBUNITS OF AT LEAST ONE 2'-DEOXYNUCLEOTIDES; INCREASED NUCLEASE RESISTANCE; ACTIVATE RNASE H ENZYME, USE FOR IN VITRO MODIFICATION OF RNA | ISIS PHARMACEUTICALS, INC. | 2001-08-21 | — | — | US | disclosed |
| US-5700922-A | INCREASED NUCLEASE RESISTANCE, INCREASED BINDING AFFINITY TO COMPLEMENTARY STRANDS; MEDICAL DIAGNOSIS, THERAPY | ISIS PHARMACEUTICALS, INC. (US) | 1997-12-23 | — | — | US | disclosed |