SCHEMBL7535814

SCHEMBL7535814

CCN(CC(=O)n1cc(C)c(=O)[nH]c1=O)NC(=O)OC(C)(C)C

nearest known ligand 0.41

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
TK1 P04183 4/20 0.35
SQOR Q9Y6N5 1/20 0.33
CTSL P07711 1/20 0.32
CTSB P07858 1/20 0.32
CTSS P25774 1/20 0.32
MAPK1 P28482 1/20 0.32
AKT1 P31749 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
HPGD P15428 1/20 0.32
TYMP P19971 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8581762 0.83 SQOR (0.39) TK1SQORMAPK1SMN1; SMN2HPGD
SCHEMBL7535820 0.74 MAOA (0.39) TK1
SCHEMBL7535825 0.73 TK1 (0.35) TK1SQORMAPK1HPGDTYMP
SCHEMBL7535823 0.73 TK1 (0.35) TK1SQORMAPK1HPGDTYMP
SCHEMBL7540436 0.73 TK1 (0.37) TK1MAPK1TYMP
SCHEMBL16653120 0.72 TK1 (0.43) TK1MAPK1HPGDTYMP
SCHEMBL13197738 0.68 CA1 (0.44) CTSLCTSBCTSSAKT1
SCHEMBL2152968 0.67 CYP1A2 (0.43) CTSLCTSBCTSSAKT1SMN1; SMN2
SCHEMBL27949444 0.66 LMNA (0.46) TK1MAPK1HPGDTYMP
SCHEMBL7198000 0.66 CA12 (0.41) CTSLCTSBCTSSAKT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0734391-B1 PNA-DNA-PNA CHIMERIC MACROMOLECULES ISIS PHARMACEUTICALS INC (US) 2002-06-12 EP disclosed
EP-1201676-A2 PNA-DNA-PNA chimeric macromolecules ISIS PHARMACEUTICALS, INC. (US) 2002-05-02 EP disclosed
US-6277603-B1 PEPTIDE NUCLEIC ACID (PNA); THE DNA PORTION IS COMPOSED OF SUBUNITS OF AT LEAST ONE 2'-DEOXYNUCLEOTIDES; INCREASED NUCLEASE RESISTANCE; ACTIVATE RNASE H ENZYME, USE FOR IN VITRO MODIFICATION OF RNA ISIS PHARMACEUTICALS, INC. 2001-08-21 US disclosed
EP-0734391-A4 PNA-DNA-PNA CHIMERIC MACROMOLECULES ISIS PHARMACEUTICALS INC (US) 1998-02-25 EP disclosed
US-5700922-A INCREASED NUCLEASE RESISTANCE, INCREASED BINDING AFFINITY TO COMPLEMENTARY STRANDS; MEDICAL DIAGNOSIS, THERAPY ISIS PHARMACEUTICALS, INC. (US) 1997-12-23 US disclosed
US-5629152-A SYNTHETIC POLYPEPTIDES WITH DOUBLE HELICAL STRUCTURE, BINDING TO DNA AND RNA STRANDS, CONTAIN AZETIDINE RING ISIS PHARMACEUTICALS, INC. (US) 1997-05-13 US disclosed
EP-0734391-A1 PNA-DNA-PNA CHIMERIC MACROMOLECULES ISIS PHARMACEUTICALS, INC. (US) 1996-10-02 EP disclosed
WO-1995014706-A1 PNA-DNA-PNA CHIMERIC MACROMOLECULES ISIS PHARMACEUTICALS, INC. (US) 1995-06-01 WO disclosed