Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.68 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.68 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.68 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.68 |
| ▸ | CCKBR | P32239 | 1/20 | 0.68 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.68 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.68 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.68 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.65 |
| ▸ | GAA | P10253 | 2/20 | 0.65 |
| ▸ | HTT | P42858 | 1/20 | 0.65 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.59 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8851595 | 0.89 | GABRA1 (0.68) | GABRA1GABRG2GABRB3GABRA5CCKBR | |
| SCHEMBL9380657 | 0.85 | HDAC3 (0.69) | GABRA1GABRG2GABRB3GABRA5CCKBR | |
| SCHEMBL11575757 | 0.85 | GABRA1 (0.60) | GABRA1GABRG2GABRB3GABRA5CCKBR | |
| SCHEMBL23560411 | 0.85 | GABRA1 (0.63) | GABRA1GABRG2GABRB3GABRA5CCKBR | |
| SCHEMBL4413309 | 0.85 | GABRA1 (0.63) | GABRA1GABRG2GABRB3GABRA5CCKBR | |
| SCHEMBL27562818 | 0.84 | NPSR1 (0.78) | GABRA1GABRG2GABRB3GABRA5CCKBR | |
| SCHEMBL5355886 | 0.84 | OPRK1 (0.73) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL12143205 | 0.84 | SMN1; SMN2 (0.67) | GABRA1GABRG2GABRB3GABRA5CCKBR | |
| SCHEMBL6985755 | 0.84 | GABRA1 (0.65) | GABRA1GABRG2GABRB3GABRA5CCKBR | |
| SCHEMBL11576814 | 0.84 | GABRA1 (0.61) | GABRA1GABRG2GABRB3GABRA5CCKBR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160222026-A1 | Dibenzo[B,F][1,4]oxazepin-11-yl-N-Hydroxybenzamides as HDAC Inhibitors | FMR LLC | 2016-08-04 | — | — | US | disclosed |
| US-20140179678-A1 | METHODS OF TARGETED TREATMENT OF FRONTOTEMPORAL LOBAR DEGENERATION | FMR LLC | 2014-06-26 | — | — | US | disclosed |
| CN-1812982-B | Benzodiazepine CGRP receptor antagonists | MERCK & CO INC | 2010-10-27 | — | — | CN | disclosed |
| EP-1024811-A4 | NOVEL BENZODIAZEPINE DERIVATIVES AS ANTIARRHYTHMIC AGENTS | MERCK & CO INC (US) | 2002-11-13 | — | — | EP | disclosed |
| US-6214823-B1 | CARDIOVASCULAR DISORDERS | MERCK & CO., INC. | 2001-04-10 | — | — | US | disclosed |
| EP-1024811-A1 | NOVEL BENZODIAZEPINE DERIVATIVES AS ANTIARRHYTHMIC AGENTS | Merck & Co., Inc. (US) | 2000-08-09 | — | — | EP | disclosed |
| WO-1999020281-A1 | NOVEL BENZODIAZEPINE DERIVATIVES AS ANTIARRHYTHMIC AGENTS | MERCK & CO., INC. (US) | 1999-04-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140179678-A1 | METHODS OF TARGETED TREATMENT OF FRONTOTEMPORAL LOBAR DEGENERATION | GRN, PRPH, TDP2 | GABRA1 2575/4885GABRG2 2820/4885GABRB3 1455/4885 |
| US-20160222026-A1 | Dibenzo[B,F][1,4]oxazepin-11-yl-N-Hydroxybenzamides as HDAC Inhibitors | HDAC1, HDAC2, HDAC4 | GABRA1 1228/4885GABRG2 1128/4885GABRB3 612/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.