SCHEMBL754268

SCHEMBL754268

Nc1ccc(CCO)c(N)c1CCO

nearest known ligand 0.32

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20210937 0.84 TDP1 (0.33) TDP1
SCHEMBL6943516 0.83 TDP1 (0.30) TDP1
SCHEMBL460054 0.81 TDP1 (0.38) TDP1
SCHEMBL9851188 0.81 KDM4E (0.38)
SCHEMBL11865372 0.79
SCHEMBL457335 0.79 TSHR (0.33)
SCHEMBL11866234 0.79 MAP4K1 (0.32)
SCHEMBL11859360 0.79 CA2 (0.30)
SCHEMBL22499986 0.78 GAA (0.39) TDP1
SCHEMBL6572335 0.77 GLA (0.30)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 120 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12178897-B2 Oxidative dyeing agent for keratin fibers comprising novel dye precursor combinations HENKEL AG & CO. KGAA (DE) 2024-12-31 US claimed
EP-3096735-A1 GRADUAL HAIRCOLOR COMPOSITIONS AND METHODS OF USING THE SAME Combe International Ltd. (US) 2016-11-30 EP claimed
WO-2016020111-A1 NOVEL OXIDATION DYE INTERMEDIATES OF THE TYPE OF OXY-, THIO-, AND AZA-BIS-BENZENES HENKEL AG & CO. KGAA (DE) 2016-02-11 WO claimed
WO-2016020110-A1 OXY-, THIO- AND AZO- BIS-BENZENE TYPE OXIDATION DYE PRECURSORS HENKEL AG & CO. KGAA (DE) 2016-02-11 WO claimed
WO-2016020112-A1 OXIDATION DYE PRECURSOR HENKEL AG & CO. KGAA (DE) 2016-02-11 WO claimed
WO-2015112789-A1 GRADUAL HAIRCOLOR COMPOSITIONS AND METHODS OF USING THE SAME COMBE INTERNATIONAL LTD. (US) 2015-07-30 WO claimed
EP-1200048-A1 NOVEL DEVELOPER-COUPLER COMBINATIONS Henkel Kommanditgesellschaft auf Aktien (DE) 2002-05-02 EP claimed
WO-2001008645-A1 NOVEL DEVELOPER-COUPLER COMBINATIONS HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 2001-02-08 WO claimed
WO-2023194511-A1 COMPOSITION FOR THE COSMETIC TREATMENT OF KERATIN FIBERS BIOSYNTHIS (FR) 2023-10-12 WO disclosed
CN-112312880-B Oxidative hair lightening or hair coloring agents with improved application properties 汉高股份有限及两合公司 2023-09-15 CN disclosed
CN-112469389-B Amine-based reaction products as functional additives 汉高股份有限及两合公司 2023-06-20 CN disclosed
CN-112312881-B Oxidative hair lightening or hair coloring agents for secondary coloring prepared cold 汉高股份有限及两合公司 2023-05-09 CN disclosed
EP-4168128-A1 THICKENED ALKALYZATION COMPONENT FOR OXIDATIVE HAIR DYEING PRODUCT Henkel AG & Co. KGaA (DE) 2023-04-26 EP disclosed
CN-115697495-A Thickening and alkalizing component for oxidative hair dyes 汉高股份有限及两合公司 2023-02-03 CN disclosed
EP-1085851-A1 COLORANTS AND USE THEREOF Henkel Kommanditgesellschaft auf Aktien (DE) 2001-03-28 EP disclosed
WO-2001015662-A2 METHOD FOR COLOURING HAIR HANS SCHWARZKOPF GMBH & CO. KG (DE) 2001-03-08 WO disclosed
WO-2000061091-A1 COLOURING AGENT AND THE USE THEREOF HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 2000-10-19 WO disclosed
WO-2000061090-A1 METHOD AND COLORANT FOR DYEING KERATIN FIBERS HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 2000-10-19 WO disclosed
WO-2000061089-A1 COLORANTS AND USE THEREOF HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 2000-10-19 WO disclosed
WO-1999066889-A1 NEW COUPLING COMPONENTS FOR OXIDATION HAIR COLOURING PRODUCTS HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 1999-12-29 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12178897-B2 Oxidative dyeing agent for keratin fibers comprising novel dye precursor combinations KRT18, ALDH5A1, COX5A TDP1 1430/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.