Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 4/20 | 0.71 |
| ▸ | DRD2 | P14416 | 4/20 | 0.52 |
| ▸ | DRD3 | P35462 | 4/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
| ▸ | HTR1B | P28222 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24734855 | 0.84 | ADRA1A (1.00) | ADRA1ADRD2DRD3CYP1A2HTR1D | |
| Hydrochloric Acid SCHEMBL8669188 | 0.82 | ADRA1A (0.96) | ADRA1ADRD2DRD3CYP1A2HTR1D | |
| Hydrochloric Acid SCHEMBL30861222 | 0.82 | ADRA1A (0.96) | ADRA1ADRD2DRD3CYP1A2HTR1D | |
| Bromide SCHEMBL25243558 | 0.82 | ADRA1A (0.96) | ADRA1ADRD2DRD3CYP1A2HTR1D | |
| SCHEMBL7540435 | 0.80 | DRD2 (0.55) | ADRA1ADRD2DRD3CYP1A2DRD4 | |
| Hydrochloric Acid SCHEMBL7543833 | 0.79 | DRD2 (0.53) | ADRA1ADRD2DRD3CYP1A2DRD4 | |
| SCHEMBL5793364 | 0.77 | ADRA1A (0.78) | ADRA1ADRD2DRD3CYP1A2HTR1D | |
| SCHEMBL4217393 | 0.77 | ADRA1A (0.78) | ADRA1ADRD2DRD3CYP1A2 | |
| SCHEMBL7549300 | 0.77 | ADRA1A (0.78) | ADRA1ADRD2DRD3CYP1A2 | |
| SCHEMBL7541153 | 0.77 | ADRA1A (0.41) | ADRA1ADRD2DRD3CYP1A2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0883599-B1 | AMINOTETRALIN DERIVATIVES AND COMPOSITIONS AND METHOD OF USE THEREOF | ASTRAZENECA AB (SE) | 2002-06-05 | — | — | EP | disclosed |
| EP-0883599-A1 | AMINOTETRALIN DERIVATIVES AND COMPOSITIONS AND METHOD OF USE THEREOF | ZENECA LIMITED (GB) | 1998-12-16 | — | — | EP | disclosed |
| US-5807897-A | MUSCULAR DISORDERS | ZENECA LIMITED (GB) | 1998-09-15 | — | — | US | disclosed |
| WO-1997031887-A1 | AMINOTETRALIN DERIVATIVES AND COMPOSITIONS AND METHOD OF USE THEREOF | ZENECA LIMITED (GB) | 1997-09-04 | — | — | WO | disclosed |