Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STING1 | Q86WV6 | 9/20 | 0.55 |
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | MDM4 | O15151 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | PARP1 | P09874 | 1/20 | 0.52 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | CFTR | P13569 | 1/20 | 0.50 |
| ▸ | DHPS | P49366 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7382967 | 0.88 | MAPT (0.57) | STING1RAB9AKMT2ATP53MAPT | |
| SCHEMBL22246525 | 0.85 | STING1 (0.72) | STING1NPC1RAB9APARP1DHPS | |
| SCHEMBL384965 | 0.84 | STING1 (0.63) | STING1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL7548968 | 0.84 | AAK1 (0.62) | MEN1KMT2AMAPT | |
| SCHEMBL22246524 | 0.84 | STING1 (0.70) | STING1NPC1RAB9AKMT2ATP53 | |
| SCHEMBL27075304 | 0.83 | NPC1 (0.68) | STING1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL3233072 | 0.83 | HPGDS (0.50) | STING1 | |
| SCHEMBL28736881 | 0.82 | STING1 (0.74) | STING1 | |
| SCHEMBL5894412 | 0.81 | STING1 (0.56) | STING1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL4490274 | 0.81 | STING1 (0.59) | STING1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0785789-B1 | DIAZEPINO-INDOLES AS PHOSPHODIESTERASE IV INHIBITORS | PFIZER (FR) | 2002-09-11 | — | — | EP | disclosed |