Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 8/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | BACE1 | P56817 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | PIM1 | P11309 | 2/20 | 0.53 |
| ▸ | GAK | O14976 | 1/20 | 0.53 |
| ▸ | STK16 | O75716 | 1/20 | 0.53 |
| ▸ | AXL | P30530 | 1/20 | 0.53 |
| ▸ | NEK2 | P51955 | 1/20 | 0.53 |
| ▸ | STK3 | Q13188 | 1/20 | 0.53 |
| ▸ | STK11 | Q15831 | 1/20 | 0.53 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7053845 | 0.85 | AAK1 (0.70) | AAK1HDAC3HDAC1HDAC2L3MBTL1 | |
| SCHEMBL7382967 | 0.85 | MAPT (0.57) | KMT2AHTTMAPTPIM1PIM2 | |
| SCHEMBL7543952 | 0.84 | STING1 (0.55) | MEN1KMT2AMAPT | |
| SCHEMBL3233072 | 0.77 | HPGDS (0.50) | AAK1HDAC3HDAC1HDAC2BACE1 | |
| SCHEMBL7112349 | 0.77 | AAK1 (1.00) | AAK1HDAC3HDAC1HDAC2PIM1 | |
| SCHEMBL28677805 | 0.76 | ALDH1A1 (0.78) | MEN1KMT2AHDAC3HDAC1HDAC2 | |
| SCHEMBL700094 | 0.76 | GPR84 (0.63) | MEN1KMT2AALDH1A1PIM1 | |
| SCHEMBL20293923 | 0.76 | CNR1 (0.49) | MEN1KMT2AHDAC2ALDH1A1HTT | |
| Nicotredole SCHEMBL735897 | 0.76 | MEN1 (1.00) | MEN1KMT2AALDH1A1 | |
| Nicotredole SCHEMBL29454469 | 0.76 | MEN1 (1.00) | MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0785789-B1 | DIAZEPINO-INDOLES AS PHOSPHODIESTERASE IV INHIBITORS | PFIZER (FR) | 2002-09-11 | — | — | EP | disclosed |