Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.34 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.34 |
| ▸ | PNMT | P11086 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | HTR2B | P41595 | 2/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
| ▸ | CA6 | P23280 | 1/20 | 0.39 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.39 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30103334 | 0.82 | PNMT (0.63) | PNMTNPC1RAB9AHTR2BHTR7 | |
| SCHEMBL524602 | 0.82 | PNMT (0.63) | PNMTNPC1RAB9AHTR2BHTR7 | |
| SCHEMBL2877998 | 0.80 | PNMT (0.61) | PNMTNPC1RAB9AHTR2BHTR7 | |
| Hydrochloric Acid SCHEMBL3385861 | 0.79 | PNMT (0.52) | PNMTNPC1RAB9AHTR2BHTR7 | |
| Hydrochloric Acid SCHEMBL30274953 | 0.79 | PNMT (0.52) | PNMTNPC1RAB9AHTR2BHTR7 | |
| SCHEMBL22263591 | 0.77 | PNMT (0.57) | PNMTNPC1RAB9AHTR2BHTR7 | |
| Hydrochloric Acid SCHEMBL540142 | 0.77 | PNMT (0.53) | PNMTNPC1RAB9AHTR2BHTR7 | |
| SCHEMBL27885618 | 0.76 | PNMT (0.57) | PNMTNPC1RAB9AHTR2BHTR7 | |
| Hydrochloric Acid SCHEMBL540483 | 0.75 | PNMT (0.52) | PNMTNPC1RAB9AHTR2BHTR7 | |
| Hydrochloric Acid SCHEMBL3381704 | 0.75 | PNMT (0.52) | PNMTNPC1RAB9AHTR2BHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0841375-B1 | Impact-resistant polystyrene resin composition | UBE INDUSTRIES (JP) | 2002-05-22 | — | — | EP | disclosed |
| EP-0778291-B1 | Catalyst and process for producing conjugated diene polymer | UBE INDUSTRIES (JP) | 2001-03-28 | — | — | EP | disclosed |
| US-6071845-A | OBTAINED BY CONTACTING A COMPOUND OF A TRANSITION METAL OF THE GROUP V OF THE PERIODIC TABLE WITH AN IONIC COMPOUND COMPRISING A NON-COORDINATING ANION AND A CATION AND AN ALUMINOXANE | UBE INDUSTRIES, LTD. (JP) | 2000-06-06 | — | — | US | disclosed |
| US-5981667-A | CONTAINING DISPERSED PARTICLES OF HIGH-CIS HIGH-VINYL POLYBUTADIENE COMPRISING FROM 65 TO 95% CIS-1,4-STRUCTURES AND FROM 30 TO 4% 1,2-STRUCTURES | UBE INDUSTRIES, LTD. (JP) | 1999-11-09 | — | — | US | disclosed |
| EP-0841375-A1 | Impact-resistant polystyrene resin composition | UBE INDUSTRIES, LTD. (JP) | 1998-05-13 | — | — | EP | disclosed |
| EP-0778291-A1 | Catalyst and process for producing conjugated diene polymer | UBE INDUSTRIES, LTD. (JP) | 1997-06-11 | — | — | EP | disclosed |