SCHEMBL7544894

SCHEMBL7544894

COC(=O)Nc1ccc(OCc2nc3ccc(F)c(F)c3o2)cc1C

nearest known ligand 0.40

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
KDR P35968 5/20 0.40
ALOX5 P09917 5/20 0.38
EPHX2 P34913 5/20 0.38
RAB9A P51151 1/20 0.38
EGFR P00533 2/20 0.37
PPARD Q03181 2/20 0.36
PPARG P37231 2/20 0.36
MEN1 O00255 1/20 0.35
HTT P42858 1/20 0.35
KMT2A Q03164 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7549421 0.91 MAPK13 (0.41) KDRALOX5EPHX2RAB9APPARG
SCHEMBL7548871 0.88 KDR (0.44) KDRALOX5EPHX2RAB9AEGFR
SCHEMBL7547406 0.85 KDR (0.46) KDRALOX5EPHX2EGFRPPARD
SCHEMBL7547594 0.85 SMN1; SMN2 (0.47) KDRRAB9AMEN1KMT2A
SCHEMBL7542077 0.83 CEPT1 (0.42) KDRALOX5EPHX2EGFR
SCHEMBL7542502 0.83 MAPT (0.46) KDRRAB9APPARDMEN1KMT2A
SCHEMBL7541091 0.82 ALOX5 (0.44) KDRALOX5EPHX2PPARDMEN1
SCHEMBL7550333 0.82 MAPT (0.46) KDRALOX5EPHX2RAB9AMEN1
SCHEMBL7543778 0.82 MAPT (0.45) KDRALOX5EPHX2RAB9AMEN1
SCHEMBL7545106 0.81 CEPT1 (0.42) KDRALOX5EPHX2RAB9AEGFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0795550-B1 Aniline derivatives having herbicidal activity their preparation and their use SANKYO CO (JP) 2002-06-05 EP disclosed
US-5736487-A HERBICIDES SANKYO COMPANY, LIMITED (JP) 1998-04-07 US disclosed
EP-0795550-A1 Aniline derivatives having herbicidal activity their preparation and their use SANKYO COMPANY LIMITED (JP) 1997-09-17 EP disclosed