Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.54 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.54 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.54 |
| ▸ | LCK | P06239 | 3/20 | 0.54 |
| ▸ | CSF1R | P07333 | 3/20 | 0.54 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.54 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.54 |
| ▸ | AURKA | O14965 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | TTK | P33981 | 3/20 | 0.54 |
| ▸ | KIT | P10721 | 2/20 | 0.54 |
| ▸ | FLT3 | P36888 | 2/20 | 0.54 |
| ▸ | PLK4 | O00444 | 2/20 | 0.54 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.54 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.54 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.54 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.54 |
| ▸ | CDK1 | P06493 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8720058 | 0.83 | PIM1 (0.41) | KDRALDH1A1MAPK10MAPK8MAPK9 | |
| SCHEMBL8717405 | 0.80 | KDR (0.44) | KDRALDH1A1MAPK10MAPK8MAPK9 | |
| SCHEMBL8717177 | 0.77 | LRRK2 (0.38) | KDRALDH1A1MAPK10MAPK8MAPK9 | |
| SCHEMBL6750942 | 0.76 | MAPK10 (0.41) | KDRALDH1A1MAPK10MAPK8MAPK9 | |
| SCHEMBL7541304 | 0.76 | KDM4E (0.41) | KDRALDH1A1MAPK10MAPK8MAPK9 | |
| SCHEMBL19044532 | 0.74 | KDM4E (0.43) | KDRALDH1A1MAPK10MAPK8MAPK9 | |
| SCHEMBL9258350 | 0.70 | KDM4E (0.56) | KDRALDH1A1MAPK10MAPK8MAPK9 | |
| SCHEMBL29941507 | 0.70 | ALDH1A1 (1.00) | KDRALDH1A1MAPK10MAPK8MAPK9 | |
| SCHEMBL29693577 | 0.70 | ALDH1A1 (1.00) | KDRALDH1A1MAPK10MAPK8MAPK9 | |
| SCHEMBL170980 | 0.70 | ALDH1A1 (1.00) | KDRALDH1A1MAPK10MAPK8MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0127389-B1 | N,N-DIETHYL-5-METHYL-2H-1-BENZOTHIOPYRANO-(4,3,2-CD)-INDAZOLE-2-ETHANAMINE, COMPOSITIONS COMPRISING THE SAME AND USES THEREFOR | WARNER-LAMBERT COMPANY (US) | 1988-09-07 | — | — | EP | claimed |
| EP-0114002-B1 | BENZOTHIOPYRANO(4,3,2,-CD)INDAZOLES, THEIR PHARMACEUTICAL COMPOSITIONS AND METHODS FOR THEIR PRODUCTION | WARNER-LAMBERT COMPANY (US) | 1987-03-04 | — | — | EP | claimed |
| EP-0114002-A2 | Benzothiopyrano(4,3,2,-cd)indazoles, their pharmaceutical compositions and methods for their production | WARNER-LAMBERT COMPANY (US) | 1984-07-25 | — | — | EP | claimed |
| EP-0812192-B1 | BENZOTHIOPYRANOINDAZOLES ANTITUMOR AGENTS | SANOFI SYNTHELABO (FR) | 2002-11-06 | — | — | EP | disclosed |
| EP-0812192-A4 | BENZOTHIOPYRANOINDAZOLES ANTITUMOR AGENTS | SANOFI WINTHROP INC (US) | 2000-03-08 | — | — | EP | disclosed |
| CN-1176597-A | Benzothiopyranoindazoles antitumor agents | SANOFI WINTHROP INC (US) | 1998-03-18 | — | — | CN | disclosed |
| EP-0812192-A1 | BENZOTHIOPYRANOINDAZOLES ANTITUMOR AGENTS | SANOFI WINTHROP, INC. (US) | 1997-12-17 | — | — | EP | disclosed |
| WO-1996026723-A1 | BENZOTHIOPYRANOINDAZOLES ANTITUMOR AGENTS | SANOFI WINTHROP, INC. (US) | 1996-09-06 | — | — | WO | disclosed |
| US-5532263-A | Benzothiopyranoindazole antitumor agents | STERLING WINTHROP INC. (US) | 1996-07-02 | — | — | US | disclosed |
| US-5532263-A | Benzothiopyranoindazole antitumor agents | STERLING WINTHROP INC. (US) | 1996-07-02 | — | — | US | disclosed |
| EP-0172632-B1 | Benzopyrano[4,3,2-cd]indazole compounds, processes for their production and pharmaceutical compositions comprising the compounds | WARNER-LAMBERT COMPANY (US) | 1989-08-30 | — | — | EP | disclosed |
| US-4604390-A | FUNGICIDES, ANTITUMOR AGENTS | WARNER-LAMBERT COMPANY (US) | 1986-08-05 | — | — | US | disclosed |
| US-4604390-A | FUNGICIDES, ANTITUMOR AGENTS | WARNER-LAMBERT COMPANY (US) | 1986-08-05 | — | — | US | disclosed |
| EP-0114002-A2 | Benzothiopyrano(4,3,2,-cd)indazoles, their pharmaceutical compositions and methods for their production | WARNER-LAMBERT COMPANY (US) | 1984-07-25 | — | — | EP | disclosed |
| EP-0114002-A2 | Benzothiopyrano(4,3,2,-cd)indazoles, their pharmaceutical compositions and methods for their production | WARNER-LAMBERT COMPANY (US) | 1984-07-25 | — | — | EP | disclosed |
| EP-0114002-A2 | Benzothiopyrano(4,3,2,-cd)indazoles, their pharmaceutical compositions and methods for their production | WARNER-LAMBERT COMPANY (US) | 1984-07-25 | — | — | EP | disclosed |
| US-4026899-A | PARASITICIDES | PARKE, DAVIS & COMPANY (US) | 1977-05-31 | — | — | US | disclosed |
| US-4026899-A | PARASITICIDES | PARKE, DAVIS & COMPANY (US) | 1977-05-31 | — | — | US | disclosed |
| US-3963740-A | PARASITICIDE | PARKE, DAVIS & COMPANY (US) | 1976-06-15 | — | — | US | disclosed |
| US-3963740-A | PARASITICIDE | PARKE, DAVIS & COMPANY (US) | 1976-06-15 | — | — | US | disclosed |