Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 4/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.44 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.44 |
| ▸ | LCK | P06239 | 3/20 | 0.44 |
| ▸ | CSF1R | P07333 | 3/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | KIT | P10721 | 2/20 | 0.44 |
| ▸ | FLT3 | P36888 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | PLK4 | O00444 | 2/20 | 0.44 |
| ▸ | AURKA | O14965 | 2/20 | 0.44 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.44 |
| ▸ | CDK1 | P06493 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8717177 | 0.80 | LRRK2 (0.38) | KDRMAPK10MAPK8MAPK9LCK | |
| SCHEMBL7544982 | 0.80 | KDR (0.54) | KDRMAPK10MAPK8MAPK9LCK | |
| SCHEMBL20256432 | 0.78 | ALDH1A1 (0.43) | MAPK10ALDH1A1HSD17B10LMNAKDM4E | |
| SCHEMBL8720058 | 0.73 | PIM1 (0.41) | KDRMAPK10MAPK8MAPK9LCK | |
| SCHEMBL9201258 | 0.70 | MEN1 (0.67) | KDRMAPK10MAPK8MAPK9LCK | |
| SCHEMBL8796647 | 0.67 | MEN1 (0.67) | KDRMAPK10MAPK8MAPK9LCK | |
| SCHEMBL20256146 | 0.66 | ALDH1A1 (0.36) | MAPK10ALDH1A1HSD17B10LMNACYP1A2 | |
| SCHEMBL21385107 | 0.64 | TYMS (0.39) | MAPK10ALDH1A1HSD17B10LMNAKDM4E | |
| SCHEMBL7541304 | 0.62 | KDM4E (0.41) | KDRMAPK10MAPK8MAPK9LCK | |
| SCHEMBL6750942 | 0.62 | MAPK10 (0.41) | KDRMAPK10MAPK8MAPK9LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0837861-A1 | NEW PYRIDO-THIOPYRANOINDAZOLES WITH ANTITUMOR ACTIVITY | THE UNIVERSITY OF VERMONT (US) | 1998-04-29 | — | — | EP | disclosed |
| WO-1997002267-A1 | NEW PYRIDO-THIOPYRANOINDAZOLES WITH ANTITUMOR ACTIVITY | UNIVERSITY OF VERMONT (US) | 1997-01-23 | — | — | WO | disclosed |