Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 5/20 | 0.41 |
| ▸ | CLK2 | P49760 | 3/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | IKBKB | O14920 | 2/20 | 0.41 |
| ▸ | AURKA | O14965 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KIT | P10721 | 2/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | FLT3 | P36888 | 2/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.41 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CDC7 | O00311 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7544982 | 0.83 | KDR (0.54) | PIM1CLK2DYRK1AMAPK8MAPK9 | |
| SCHEMBL8717177 | 0.74 | LRRK2 (0.38) | PIM1CLK2DYRK1AMAPK8MAPK9 | |
| SCHEMBL8720060 | 0.73 | GAA (0.40) | DYRK1AMAPTPDPK1IDO1GAA | |
| SCHEMBL8717405 | 0.73 | KDR (0.44) | PIM1CLK2DYRK1AMAPK8MAPK9 | |
| SCHEMBL7817760 | 0.71 | PIM1 (0.72) | PIM1CLK2DYRK1AMAPK8MAPK9 | |
| SCHEMBL7810309 | 0.71 | TTK (0.72) | PIM1CLK2DYRK1AMAPK8MAPK9 | |
| SCHEMBL8716395 | 0.65 | TOP2A (0.35) | MAPTCYP1A2CYP3A4CYP2D6IDO1 | |
| SCHEMBL8717236 | 0.65 | GAA (0.36) | MAPTPDPK1IDO1GAAL3MBTL1 | |
| SCHEMBL6750942 | 0.62 | MAPK10 (0.41) | PIM1CLK2DYRK1AMAPK8MAPK9 | |
| SCHEMBL7541304 | 0.62 | KDM4E (0.41) | PIM1CLK2DYRK1AMAPK8MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0837861-A1 | NEW PYRIDO-THIOPYRANOINDAZOLES WITH ANTITUMOR ACTIVITY | THE UNIVERSITY OF VERMONT (US) | 1998-04-29 | — | — | EP | disclosed |
| WO-1997002267-A1 | NEW PYRIDO-THIOPYRANOINDAZOLES WITH ANTITUMOR ACTIVITY | UNIVERSITY OF VERMONT (US) | 1997-01-23 | — | — | WO | disclosed |