Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | KDR | P35968 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.41 |
| ▸ | LCK | P06239 | 3/20 | 0.41 |
| ▸ | CSF1R | P07333 | 3/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.41 |
| ▸ | AURKA | O14965 | 3/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | KIT | P10721 | 2/20 | 0.41 |
| ▸ | FLT3 | P36888 | 2/20 | 0.41 |
| ▸ | PLK4 | O00444 | 2/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6750942 | 0.82 | MAPK10 (0.41) | KDM4EKDRALDH1A1MAPK8MAPK9 | |
| SCHEMBL7544982 | 0.76 | KDR (0.54) | KDM4EKDRALDH1A1MAPK8MAPK9 | |
| SCHEMBL18292352 | 0.69 | KMT2A (0.60) | KDM4EKDRALDH1A1MAPK8MAPK9 | |
| SCHEMBL10923929 | 0.67 | NPY5R (0.35) | PIM1EIF2AK2MAPK12NPY5RMAPK14 | |
| SCHEMBL10925471 | 0.64 | TOP2A (0.39) | KDM4EALDH1A1MAPTPOLBMEN1 | |
| SCHEMBL8717405 | 0.62 | KDR (0.44) | KDM4EKDRALDH1A1MAPK8MAPK9 | |
| SCHEMBL8720058 | 0.62 | PIM1 (0.41) | KDM4EKDRALDH1A1MAPK8MAPK9 | |
| SCHEMBL7946079 | 0.60 | KDR (0.65) | KDM4EKDRALDH1A1MAPK8MAPK9 | |
| SCHEMBL2768654 | 0.60 | ALDH1A1 (0.60) | KDM4EKDRALDH1A1MAPK8MAPK9 | |
| SCHEMBL2771305 | 0.59 | MAPK8 (0.57) | KDM4EKDRALDH1A1MAPK8MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0812192-B1 | BENZOTHIOPYRANOINDAZOLES ANTITUMOR AGENTS | SANOFI SYNTHELABO (FR) | 2002-11-06 | — | — | EP | disclosed |
| EP-0812192-A4 | BENZOTHIOPYRANOINDAZOLES ANTITUMOR AGENTS | SANOFI WINTHROP INC (US) | 2000-03-08 | — | — | EP | disclosed |
| EP-0812192-A1 | BENZOTHIOPYRANOINDAZOLES ANTITUMOR AGENTS | SANOFI WINTHROP, INC. (US) | 1997-12-17 | — | — | EP | disclosed |
| WO-1996026723-A1 | BENZOTHIOPYRANOINDAZOLES ANTITUMOR AGENTS | SANOFI WINTHROP, INC. (US) | 1996-09-06 | — | — | WO | disclosed |
| US-5532263-A | Benzothiopyranoindazole antitumor agents | STERLING WINTHROP INC. (US) | 1996-07-02 | — | — | US | disclosed |