Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.49 |
| ▸ | NPC1 | O15118 | 5/20 | 0.49 |
| ▸ | RAB9A | P51151 | 5/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | ACHE | P22303 | 7/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | STAT1 | P42224 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7545282 | 0.86 | SMN1; SMN2 (0.51) | SMN1; SMN2NPC1RAB9ALMNAGAA | |
| SCHEMBL15348811 | 0.72 | GAA (0.64) | SMN1; SMN2NPC1RAB9ALMNAGAA | |
| SCHEMBL30475381 | 0.70 | ACHE (0.56) | GAAACHE | |
| SCHEMBL31614616 | 0.70 | ACHE (0.55) | SMN1; SMN2NPC1RAB9ALMNAL3MBTL1 | |
| SCHEMBL10580487 | 0.70 | ACHE (0.55) | SMN1; SMN2NPC1RAB9ALMNAL3MBTL1 | |
| SCHEMBL7277280 | 0.70 | SMN1; SMN2 (0.52) | SMN1; SMN2NPC1RAB9ALMNAGAA | |
| SCHEMBL7552785 | 0.70 | SMN1; SMN2 (0.49) | SMN1; SMN2NPC1RAB9ALMNAGAA | |
| SCHEMBL15738570 | 0.69 | SMN1; SMN2 (0.92) | SMN1; SMN2NPC1RAB9ALMNAL3MBTL1 | |
| SCHEMBL8507123 | 0.69 | HPGD (0.67) | SMN1; SMN2RAB9AL3MBTL1ALDH1A1HPGD | |
| SCHEMBL28522595 | 0.68 | ACHE (0.56) | SMN1; SMN2NPC1RAB9ALMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1212301-A1 | ARYLALKYLOXYALKYLAMINES AND ARYLALKYLTHIOALKYLAMINES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS INHIBITORS OF NICOTINIC CHOLINERGIC RECEPTORS | Targacept, Inc. (US) | 2002-06-12 | — | — | EP | disclosed |
| WO-2001016107-A1 | ARYLALKYLOXYALKYLAMINES AND ARYLALKYLTHIOALKYLAMINES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS INHIBITORS OF NICOTINIC CHOLINERGIC RECEPTORS | TARGACEPT, INC. (US) | 2001-03-08 | — | — | WO | disclosed |