Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.68 |
| ▸ | NPC1 | O15118 | 6/20 | 0.65 |
| ▸ | RAB9A | P51151 | 6/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.58 |
| ▸ | FAAH | O00519 | 2/20 | 0.57 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28999858 | 1.00 | LMNA (0.69) | LMNAALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL28999833 | 0.94 | FAAH (0.64) | LMNAALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL108267 | 0.93 | LMNA (0.62) | LMNAALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL28999855 | 0.93 | NPC1 (0.62) | LMNAALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL179083 | 0.89 | LMNA (0.64) | LMNAALDH1A1NPC1RAB9AHPGD | |
| SCHEMBL28999835 | 0.89 | FAAH (0.60) | LMNAALDH1A1NPC1RAB9AFAAH | |
| SCHEMBL28999840 | 0.89 | ALDH1A1 (0.69) | LMNAALDH1A1SMN1; SMN2FAAH | |
| SCHEMBL28742237 | 0.87 | LMNA (0.62) | LMNAALDH1A1NPC1RAB9AHPGD | |
| SCHEMBL28999846 | 0.85 | NPC1 (0.58) | LMNAALDH1A1NPC1RAB9AHPGD | |
| SCHEMBL28999856 | 0.85 | KMT2A (0.57) | LMNAALDH1A1NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1200410-A1 | ISOQUINOLINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME, AND A PROCESS FOR THE PREPARATION OF THE ACTIVE SUBSTANCE | Egis Gyogyszergyar Rt. (HU) | 2002-05-02 | — | — | EP | disclosed |
| WO-2001009101-A1 | ISOQUINOLINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME, AND A PROCESS FOR THE PREPARATION OF THE ACTIVE SUBSTANCE | EGIS Gyógyszergyár Rt. (HU) | 2001-02-08 | — | — | WO | disclosed |