Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
| ▸ | FLT4 | P35916 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | RORB | Q92753 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | PYGL | P06737 | 1/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | KCNMA1 | Q12791 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7553937 | 0.90 | ALDH1A1 (0.43) | FLT1FLT4KDRRORBMAPK1 | |
| SCHEMBL8798631 | 0.84 | RORB (0.47) | RORBRAB9AMAPK13MAPK12MAPK11 | |
| SCHEMBL7549213 | 0.84 | L3MBTL1 (0.41) | FLT1FLT4KDRABL1MAPT | |
| SCHEMBL8805528 | 0.81 | MAPK14 (0.40) | MAPK1MAPTJAK2MAPK13MAPK12 | |
| SCHEMBL8804801 | 0.81 | RECQL (0.46) | RORBRAB9AJAK2POLBNPC1 | |
| SCHEMBL8692501 | 0.75 | FLT1 (0.41) | FLT1FLT4KDRRORBMAPK1 | |
| SCHEMBL7544426 | 0.74 | HPGD (0.42) | MAPTRAB9APYGLMAPK13MAPK12 | |
| SCHEMBL7546982 | 0.74 | SCN10A (0.36) | KDRMAPK1MAPTJAK2MAPK13 | |
| SCHEMBL1423874 | 0.73 | FLT1 (0.55) | FLT1FLT4KDRABL1MAPT | |
| SCHEMBL7554905 | 0.73 | L3MBTL1 (0.41) | FLT1FLT4KDRRAB9AJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997049708-A9 | TRICYCLIC BENZAZEPINE VASOPRESSIN ANTAGONISTS | — | 1998-05-22 | — | — | WO | disclosed |
| EP-0811008-A1 | BICYCLIC BENZAZEPINE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | American Cyanamid Company (US) | 1997-12-10 | — | — | EP | disclosed |
| EP-0804420-A1 | TRICYCLIC BENZAZEPINE VASOPRESSIN ANTAGONISTS | American Cyanamid Company (US) | 1997-11-05 | — | — | EP | disclosed |