Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.50 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7242607 | 0.79 | OPRM1 (0.53) | SMN1; SMN2KDM4EALDH1A1OPRM1SIGMAR1 | |
| SCHEMBL924276 | 0.74 | OPRM1 (0.77) | OPRM1SIGMAR1OPRD1CHRM2CHRM3 | |
| SCHEMBL3775423 | 0.72 | OPRD1 (0.54) | SMN1; SMN2KDM4EALDH1A1OPRM1SIGMAR1 | |
| SCHEMBL7487237 | 0.71 | CHRM2 (0.65) | SMN1; SMN2KDM4EALDH1A1SIGMAR1OPRD1 | |
| SCHEMBL20742038 | 0.68 | OPRM1 (0.59) | OPRM1SIGMAR1OPRD1CHRM3 | |
| SCHEMBL7487718 | 0.68 | SIGMAR1 (0.74) | SMN1; SMN2KDM4EALDH1A1SIGMAR1HRH3 | |
| SCHEMBL5744006 | 0.68 | KDM4E (1.00) | SMN1; SMN2KDM4EALDH1A1HRH3MEN1 | |
| SCHEMBL19501210 | 0.68 | OPRM1 (0.62) | OPRM1SIGMAR1OPRD1CHRM3 | |
| SCHEMBL6045571 | 0.68 | OPRM1 (1.00) | OPRM1SIGMAR1OPRD1CHRM2CHRM3 | |
| SCHEMBL4034421 | 0.68 | KCNH2 (0.61) | SMN1; SMN2KDM4EALDH1A1OPRM1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1212299-A1 | SUBSTITUTED PIPERIDINE COMPOUNDS USEFUL AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | AstraZeneca UK Limited (GB) | 2002-06-12 | — | — | EP | disclosed |
| WO-2001014333-A1 | SUBSTITUTED PIPERIDINE COMPOUNDS USEFUL AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | ASTRAZENECA UK LIMITED (GB) | 2001-03-01 | — | — | WO | disclosed |