Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.52 |
| ▸ | AURKA | O14965 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | IDH2 | P48735 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | GMNN | O75496 | 1/20 | 0.50 |
| ▸ | TTR | P02766 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.50 |
| ▸ | DHODH | Q02127 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6663767 | 0.78 | AURKA (0.72) | KIF11AURKALMNAIDH2ALDH1A1 | |
| SCHEMBL31501743 | 0.78 | AURKA (0.72) | KIF11AURKALMNAIDH2ALDH1A1 | |
| SCHEMBL9833566 | 0.77 | HTR3E (0.47) | KMT2AGRM4EGFRABCG2HTT | |
| SCHEMBL8725876 | 0.76 | HSD17B10 (0.42) | AURKAALDH1A1MEN1NFKB1PTGS1 | |
| SCHEMBL394991 | 0.75 | KIF11 (0.70) | KIF11AURKALMNAIDH2ALDH1A1 | |
| SCHEMBL30754777 | 0.74 | LMNA (0.65) | KIF11AURKALMNAIDH2ALDH1A1 | |
| SCHEMBL4656669 | 0.74 | CTSC (0.65) | KIF11AURKALMNAIDH2ALDH1A1 | |
| SCHEMBL30128849 | 0.74 | CTSC (0.65) | KIF11AURKALMNAIDH2ALDH1A1 | |
| SCHEMBL693983 | 0.74 | IDH2 (0.54) | KIF11AURKALMNAIDH2ALDH1A1 | |
| SCHEMBL1921482 | 0.71 | KIF11 (0.70) | KIF11AURKAIDH2ALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002048102-A2 | ISOCOUMARIN INHIBITING PRODUCTION OF AMYLOID PEPTIDE, PREPARATION, COMPOSITIONS CONTAINING SAME AND USES | TROPHOS (FR) | 2002-06-20 | — | — | WO | claimed |
| US-4900749-A | Isoprenoidamine compounds useful as antiulcer agents | SHIONOGI & CO., LTD. (JP) | 1990-02-13 | — | — | US | claimed |
| US-4355034-A | Ethenyl derivatives of mercaptoalkylpyridines as anti-inflammatory agents | MERCK & CO., INC. (US) | 1982-10-19 | — | — | US | claimed |
| CN-107847484-B | Nitroxide free radicals for the treatment of respiratory diseases | 耶路撒冷希伯来大学伊森姆研究发展公司 | 2021-07-06 | — | — | CN | disclosed |
| WO-2002048102-A2 | ISOCOUMARIN INHIBITING PRODUCTION OF AMYLOID PEPTIDE, PREPARATION, COMPOSITIONS CONTAINING SAME AND USES | TROPHOS (FR) | 2002-06-20 | — | — | WO | disclosed |
| EP-0428437-B1 | 1,2-Benzisoxazole derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1994-08-17 | — | — | EP | disclosed |
| EP-0428437-A1 | 1,2-Benzisoxazole derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1991-05-22 | — | — | EP | disclosed |
| EP-0195582-B1 | 5-AMINOSALICYLIC ACID DERIVATIVES OF NON-STEROIDAL ANTIINFLAMMATORY ACIDS | SMITH KLINE DAUELSBERG GmbH (DE) | 1990-01-24 | — | — | EP | disclosed |
| US-4851443-A | NON-STEROIDAL ANTIINFLAMMATORY; DERIVATIVES OF 5-AMINOSALICYLIC ACID | SMITH KLINE DAUELSBERG, GMBH (DE) | 1989-07-25 | — | — | US | disclosed |
| US-4783487-A | N-(1-carboxy-2-hydroxy-5-phenyl)-2-(6-methoxy-2-naphthyl)propionamide and anti-inflammatory use thereof | SMITH KLINE DAUELSBERG GMBH (DE) | 1988-11-08 | — | — | US | disclosed |
| WO-1986005485-A1 | AMIDES OF NON-STEROIDAL ANTI-INFLAMMATORY CARBOXYLIC ACIDS | SMITH KLINE DAUELSBERG GMBH (DE) | 1986-09-25 | — | — | WO | disclosed |
| EP-0195582-A1 | 5-Aminosalicylic acid derivatives of non-steroidal antiinflammatory acids | SMITH KLINE DAUELSBERG GmbH (DE) | 1986-09-24 | — | — | EP | disclosed |
| US-4362738-A | ANTIINFLAMMATORIES | DR. KARL THOMAE GMBH (DE) | 1982-12-07 | — | — | US | disclosed |
| EP-0024282-A1 | Benzoyl derivatives, their preparation and their use as medicines | Dr. Karl Thomae GmbH (DE) | 1981-03-04 | — | — | EP | disclosed |
| US-4212976-A | ANTIARTHRITIC AGENTS | MERCK & CO., INC. (US) | 1980-07-15 | — | — | US | disclosed |
| US-4057637-A | RHEUMATOID ARTHRITIS | MERCK & CO., INC. (US) | 1977-11-08 | — | — | US | disclosed |
| US-3971797-A | ANTIARTHRITIC | MERCK & CO., INC. (US) | 1976-07-27 | — | — | US | disclosed |