Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.48 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | CYP4Z1 | Q86W10 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | REN | P00797 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL7548037 | 0.80 | CA12 (0.50) | MAPTPKMALOX5 | |
| SCHEMBL6042500 | 0.76 | CYP4F2 (0.47) | CYP4F2CYP4A11HRH3CYP4Z1ALDH1A1 | |
| SCHEMBL7544523 | 0.75 | REN (0.67) | REN | |
| SCHEMBL7076465 | 0.75 | HRH3 (0.45) | CYP4F2CYP4A11HRH3CYP4Z1ALDH1A1 | |
| SCHEMBL6042417 | 0.75 | REN (0.37) | REN | |
| Bicarbonate SCHEMBL7445647 | 0.73 | JAK3 (0.38) | MAPTPKM | |
| Bicarbonate SCHEMBL7443967 | 0.73 | MAPT (0.49) | MAPTPKM | |
| SCHEMBL17485168 | 0.72 | MAPT (0.60) | MAPTPKMREN | |
| SCHEMBL5931598 | 0.72 | CYP4F2 (0.54) | CYP4F2CYP4A11HRH3CYP4Z1 | |
| SCHEMBL68902 | 0.72 | CYP4F2 (0.85) | MAPTCYP4F2CYP4A11HRH3CYP4Z1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863875-A1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | F. HOFFMANN-LA ROCHE AG (CH) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997009311-A1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | F. HOFFMANN-LA ROCHE AG (CH) | 1997-03-13 | — | — | WO | disclosed |