Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 6/20 | 0.49 |
| ▸ | GRIN2D | O15399 | 4/20 | 0.49 |
| ▸ | GRIN3B | O60391 | 4/20 | 0.49 |
| ▸ | GRIN2A | Q12879 | 4/20 | 0.49 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.49 |
| ▸ | GRIN2C | Q14957 | 4/20 | 0.49 |
| ▸ | GRIN3A | Q8TCU5 | 4/20 | 0.49 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.39 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7549570 | 0.91 | GRIN1 (0.52) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B | |
| SCHEMBL7550297 | 0.86 | GRIN1 (0.41) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B | |
| SCHEMBL7657650 | 0.81 | MTNR1A (0.44) | KDM4EALDH1A1HPGDMEN1MAPT | |
| SCHEMBL7547159 | 0.80 | MTNR1A (0.36) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B | |
| SCHEMBL7548639 | 0.77 | MTNR1A (0.32) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B | |
| SCHEMBL7549043 | 0.76 | MTNR1A (0.33) | KDM4EALDH1A1HPGDMAPTMTNR1A | |
| SCHEMBL7548899 | 0.75 | GRIN2D (0.40) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B | |
| SCHEMBL7648683 | 0.74 | GRIN1 (0.45) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B | |
| SCHEMBL7547267 | 0.74 | MTNR1A (0.32) | MAPTMTNR1AMTNR1B | |
| SCHEMBL7554385 | 0.73 | GLS (0.30) | MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0657427-B1 | Tricyclic indole-2-carboxylic acid derivatives being selective antagonists of the NMDA receptor | SUMITOMO PHARMA (JP) | 2002-06-19 | — | — | EP | disclosed |
| US-5496843-A | Tricyclic indole-2-carboxylic acid derivatives | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1996-03-05 | — | — | US | disclosed |
| EP-0657427-A1 | Tricyclic indole-2-carboxylic acid derivatives being selective antagonists of the NMDA receptor | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1995-06-14 | — | — | EP | disclosed |