Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.63 |
| ▸ | MAPT | P10636 | 4/20 | 0.63 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | PARP1 | P09874 | 2/20 | 0.44 |
| ▸ | PRKCI | P41743 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | PDE2A | O00408 | 1/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7547477 | 0.76 | KDM4E (0.44) | GAAKMT2AMAPTLMNAALDH1A1 | |
| SCHEMBL11547422 | 0.75 | SRC (0.56) | GAAKMT2AMAPTALDH1A1PARP1 | |
| SCHEMBL11546486 | 0.73 | KDM4E (0.64) | GAAKMT2AMAPTLMNAALDH1A1 | |
| SCHEMBL11549367 | 0.73 | TOP2A (0.50) | GAAKMT2AMAPTALDH1A1PARP1 | |
| SCHEMBL7978792 | 0.72 | ALDH1A1 (0.58) | GAAKMT2AMAPTLMNAALDH1A1 | |
| SCHEMBL599844 | 0.71 | PDE3B (0.44) | GAAKMT2AMAPTLMNAALDH1A1 | |
| SCHEMBL31014283 | 0.70 | NPSR1 (0.68) | GAAKMT2AMAPTLMNAALDH1A1 | |
| SCHEMBL634894 | 0.70 | PARP1 (0.53) | GAAKMT2AMAPTLMNAALDH1A1 | |
| SCHEMBL9006262 | 0.70 | KMT2A (0.55) | GAAKMT2AMAPTLMNAALDH1A1 | |
| SCHEMBL11548431 | 0.69 | TOP2A (0.46) | GAAKMT2AMAPTLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0273176-B1 | FUSED HETEROCYCLIC TETRAHYDROAMINOQUINOLINOLS AND RELATED COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-06-24 | — | — | EP | disclosed |
| EP-0141608-A3 | PYRAZOLOPYRIDINE CYCLOALKANONE DERIVATIVES | ICI AMERICAS INC. (US) | 1988-03-02 | — | — | EP | disclosed |
| US-4546104-A | Pyrazolopyridine cycloalkanones and process for their preparation | ICI AMERICAS INC. (US) | 1985-10-08 | — | — | US | disclosed |
| US-4546104-A | Pyrazolopyridine cycloalkanones and process for their preparation | ICI AMERICAS INC. (US) | 1985-10-08 | — | — | US | disclosed |
| EP-0141608-A2 | Pyrazolopyridine cycloalkanone derivatives | ICI AMERICAS INC. (US) | 1985-05-15 | — | — | EP | disclosed |