Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.35 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 3/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.35 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.35 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | THRA | P10827 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL649159 | 0.82 | TSHR (0.46) | TSHRIDO1SMN1; SMN2AGXT | |
| SCHEMBL3140637 | 0.81 | APP (0.46) | APPTSHRIDO1SIRT2SIRT1 | |
| SCHEMBL11215660 | 0.81 | TDP1 (0.42) | KMT2AMEN1TSHRRAPGEF4ALDH1A1 | |
| SCHEMBL19978009 | 0.79 | APP (0.54) | APPALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL3617649 | 0.78 | RAPGEF4 (0.55) | KMT2AMEN1TSHRRAPGEF4ALDH1A1 | |
| SCHEMBL9628682 | 0.78 | TSHR (0.48) | TSHRIDO1NTRK1SMN1; SMN2AGXT | |
| SCHEMBL18905641 | 0.78 | TSHR (0.48) | APPTSHRRAPGEF4ADRA2AADRA1A | |
| SCHEMBL13274041 | 0.76 | SOD1 (0.42) | TSHRRAPGEF4ALDH1A1IDO1SMN1; SMN2 | |
| SCHEMBL18180057 | 0.76 | APP (0.50) | APPTSHRALDH1A1HPGDNTRK1 | |
| Hydrochloric Acid SCHEMBL2868312 | 0.76 | RAPGEF4 (0.53) | KMT2AMEN1RAPGEF4ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1214288-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE | Targacept Inc. (US) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001017943-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE | TARGACEPT, INC. (US) | 2001-03-15 | — | — | WO | disclosed |
| EP-1042274-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE | R.J. REYNOLDS TOBACCO COMPANY (US) | 2000-10-11 | — | — | EP | disclosed |
| WO-2000023418-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE | R.J. REYNOLDS TOBACCO COMPANY (US) | 2000-04-27 | — | — | WO | disclosed |