Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.43 |
| ▸ | RECQL | P46063 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7547819 | 1.00 | TSHR (0.43) | TSHRALDH1A1RECQLCYP3A4MAPT | |
| SCHEMBL7548336 | 0.84 | CHRNB2 (0.43) | TSHRALDH1A1RECQLCYP3A4MAPT | |
| SCHEMBL7548328 | 0.84 | CHRNB2 (0.43) | TSHRALDH1A1RECQLCYP3A4MAPT | |
| SCHEMBL7548332 | 0.74 | ALDH1A1 (0.41) | ALDH1A1RECQLMAPTMEN1KMT2A | |
| SCHEMBL7548331 | 0.74 | ALDH1A1 (0.41) | ALDH1A1RECQLMAPTMEN1KMT2A | |
| SCHEMBL16958121 | 0.74 | ALDH1A1 (0.55) | TSHRALDH1A1RECQLCYP3A4MAPT | |
| SCHEMBL31482891 | 0.74 | MAPT (0.55) | TSHRALDH1A1RECQLCYP3A4MAPT | |
| SCHEMBL11231070 | 0.74 | MAPT (0.55) | TSHRALDH1A1RECQLCYP3A4MAPT | |
| SCHEMBL17978452 | 0.74 | ALDH1A1 (0.54) | TSHRALDH1A1RECQLCYP3A4MAPT | |
| SCHEMBL2918644 | 0.74 | TSHR (0.55) | TSHRALDH1A1RECQLCYP3A4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1214288-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE | Targacept Inc. (US) | 2002-06-19 | — | — | EP | disclosed |
| US-6337351-B1 | AROMATIC OLEFIN AMINES | TARGACEPT, INC. | 2002-01-08 | — | — | US | disclosed |
| WO-2001017943-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE | TARGACEPT, INC. (US) | 2001-03-15 | — | — | WO | disclosed |