Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7548331 | 1.00 | ALDH1A1 (0.41) | ALDH1A1HTTMAPTTDP1MAPK1 | |
| SCHEMBL7548336 | 0.88 | CHRNB2 (0.43) | ALDH1A1HTTMAPTTDP1MAPK1 | |
| SCHEMBL7548328 | 0.88 | CHRNB2 (0.43) | ALDH1A1HTTMAPTTDP1MAPK1 | |
| SCHEMBL7550283 | 0.76 | CHRNB2 (0.43) | ALDH1A1MAPTTDP1MAPK1MEN1 | |
| SCHEMBL7550285 | 0.76 | CHRNB2 (0.43) | ALDH1A1MAPTTDP1MAPK1MEN1 | |
| SCHEMBL7547819 | 0.74 | TSHR (0.43) | ALDH1A1HTTMAPTTDP1MAPK1 | |
| SCHEMBL7547823 | 0.74 | TSHR (0.43) | ALDH1A1HTTMAPTTDP1MAPK1 | |
| SCHEMBL30430459 | 0.69 | MCOLN3 (0.56) | ALDH1A1HTTMAPTMAPK1RECQL | |
| SCHEMBL274368 | 0.69 | MCOLN3 (0.56) | ALDH1A1HTTMAPTMAPK1RECQL | |
| SCHEMBL23671598 | 0.68 | ALDH1A1 (0.50) | ALDH1A1HTTMAPTTDP1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1214288-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE | Targacept Inc. (US) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001017943-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE | TARGACEPT, INC. (US) | 2001-03-15 | — | — | WO | disclosed |