SCHEMBL7547832

SCHEMBL7547832

CNCCCOCc1cccc(OC)c1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRM2 P08172 2/20 0.62
CHRM1 P11229 1/20 0.62
CHRM3 P20309 1/20 0.62
IDO1 P14902 2/20 0.53
AGXT P21549 2/20 0.53
ALDH1A1 P00352 2/20 0.51
KDM4E B2RXH2 1/20 0.51
MEN1 O00255 1/20 0.51
KMT2A Q03164 1/20 0.51
HTR1A P08908 1/20 0.49
ADRA1D P25100 1/20 0.49
ADRA1A P35348 1/20 0.49
ADRA1B P35368 1/20 0.49
SCN8A Q9UQD0 1/20 0.49
HTR1B P28222 1/20 0.47
MAOB P27338 4/20 0.47
MTNR1A P48039 1/20 0.46
MTNR1B P49286 1/20 0.46
TAAR1 Q96RJ0 3/20 0.45
TDP1 Q9NUW8 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14001454 0.94 CHRM2 (0.59) CHRM2CHRM1CHRM3IDO1AGXT
SCHEMBL23640522 0.83 IDO1 (0.57) CHRM2CHRM1CHRM3IDO1AGXT
SCHEMBL4734636 0.83 IDO1 (0.57) IDO1AGXTALDH1A1KDM4EMEN1
SCHEMBL3454548 0.81 IDO1 (0.56) IDO1AGXTALDH1A1KDM4EMEN1
SCHEMBL7547865 0.81 ADRB2 (0.45) CHRM2CHRM1CHRM3ALDH1A1KDM4E
SCHEMBL18551301 0.81 HTR1B (0.42) CHRM2CHRM1CHRM3ALDH1A1KDM4E
SCHEMBL30230308 0.81 IDO1 (0.50) IDO1ALDH1A1MEN1KMT2AHTR1A
SCHEMBL28385449 0.81 CHRM2 (0.60) CHRM2CHRM1CHRM3IDO1AGXT
SCHEMBL6267704 0.81 CHRM2 (0.81) CHRM2CHRM1CHRM3MEN1KMT2A
SCHEMBL7552826 0.81 L3MBTL1 (0.56) CHRM2IDO1AGXTKDM4EHTR1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1212301-A1 ARYLALKYLOXYALKYLAMINES AND ARYLALKYLTHIOALKYLAMINES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS INHIBITORS OF NICOTINIC CHOLINERGIC RECEPTORS Targacept, Inc. (US) 2002-06-12 EP disclosed
WO-2001016107-A1 ARYLALKYLOXYALKYLAMINES AND ARYLALKYLTHIOALKYLAMINES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS INHIBITORS OF NICOTINIC CHOLINERGIC RECEPTORS TARGACEPT, INC. (US) 2001-03-08 WO disclosed