Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 2/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.44 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | DRD2 | P14416 | 3/20 | 0.37 |
| ▸ | DRD3 | P35462 | 3/20 | 0.37 |
| ▸ | EEF2K | O00418 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 2/20 | 0.34 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.34 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CUL4A | Q13619 | 1/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.32 |
| ▸ | HTR5A | P47898 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24482370 | 0.81 | DRD2 (0.42) | CHRNB2CHRNA4CHRNA7KDM4EDRD2 | |
| SCHEMBL3263345 | 0.78 | GID4 (0.40) | KDM4EKDM1AALDH1A1HTR2CHTR2B | |
| SCHEMBL1721503 | 0.78 | TRPM5 (0.42) | KDM4EKDM1AAADATALDH1A1HPGD | |
| SCHEMBL3032214 | 0.78 | CUL4A (0.39) | CHRNB2CHRNA4CUL4AHTR2CHTR2B | |
| SCHEMBL7431326 | 0.68 | GRIN2D (0.41) | CHRNB2CHRNA4KDM1AHTR2CHTR2B | |
| SCHEMBL1722308 | 0.68 | GRIN2D (0.41) | CHRNB2CHRNA4KDM1AHTR2CHTR2B | |
| SCHEMBL30308765 | 0.68 | GID4 (0.45) | KDM4EDRD2KDM1AALDH1A1 | |
| SCHEMBL20478461 | 0.68 | GID4 (0.45) | KDM4EDRD2KDM1AALDH1A1 | |
| SCHEMBL12362682 | 0.68 | CHRNB2 (0.44) | CHRNB2CHRNA4CHRNA7DRD2DRD3 | |
| SCHEMBL20532511 | 0.67 | KDM4E (0.47) | CHRNB2CHRNA4KDM4EEEF2KALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0940386-B1 | Benzocyclobutan compounds, their process for preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2002-05-22 | — | — | EP | disclosed |
| US-6107345-A | ANTIDEPRESSANT; PSYCHOLOGICAL DISORDERS | ADIR ET COMPAGNIE (FR) | 2000-08-22 | — | — | US | disclosed |
| EP-0940386-A1 | Benzocyclobutan compounds, their process for preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1999-09-08 | — | — | EP | disclosed |