Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | STAT3 | P40763 | 2/20 | 0.38 |
| ▸ | AGER | Q15109 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 2/20 | 0.35 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA4 | P22748 | 1/20 | 0.34 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | STAT5B | P51692 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.34 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6252520 | 1.00 | MMP13 (0.40) | MMP13KMT2AMEN1ALDH1A1STAT3 | |
| SCHEMBL6268401 | 1.00 | MMP13 (0.40) | MMP13KMT2AMEN1ALDH1A1STAT3 | |
| SCHEMBL9459965 | 0.85 | MMP13 (0.45) | MMP13KMT2AMEN1ALDH1A1STAT3 | |
| SCHEMBL31072914 | 0.85 | MMP13 (0.45) | MMP13KMT2AMEN1ALDH1A1STAT3 | |
| SCHEMBL7521777 | 0.81 | MMP13 (0.39) | MMP13KMT2AMEN1ALDH1A1AGER | |
| SCHEMBL7599281 | 0.79 | KMT2A (0.42) | MMP13KMT2AMEN1ALDH1A1STAT3 | |
| SCHEMBL18546830 | 0.78 | AGER (0.41) | KMT2AMEN1ALDH1A1STAT3AGER | |
| SCHEMBL18546850 | 0.78 | AGER (0.41) | KMT2AMEN1ALDH1A1STAT3AGER | |
| SCHEMBL18546831 | 0.78 | AGER (0.41) | KMT2AMEN1ALDH1A1STAT3AGER | |
| SCHEMBL29089377 | 0.77 | F2 (0.39) | MMP13KMT2AMEN1ALDH1A1STAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1212301-A1 | ARYLALKYLOXYALKYLAMINES AND ARYLALKYLTHIOALKYLAMINES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS INHIBITORS OF NICOTINIC CHOLINERGIC RECEPTORS | Targacept, Inc. (US) | 2002-06-12 | — | — | EP | disclosed |
| WO-2001016107-A1 | ARYLALKYLOXYALKYLAMINES AND ARYLALKYLTHIOALKYLAMINES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS INHIBITORS OF NICOTINIC CHOLINERGIC RECEPTORS | TARGACEPT, INC. (US) | 2001-03-08 | — | — | WO | disclosed |