Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.41 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.41 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.41 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.41 |
| ▸ | FEN1 | P39748 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 5/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8723935 | 0.88 | TSHR (0.61) | TSHRCXCL12JAK2TAS1R3TAS1R1 | |
| SCHEMBL7549234 | 0.80 | TSHR (0.55) | TSHRCXCL12JAK2TAS1R3TAS1R1 | |
| SCHEMBL21949122 | 0.74 | P2RX7 (0.43) | TSHRTAS1R3TAS1R1TAS1R2CYP2C9 | |
| SCHEMBL2652860 | 0.73 | ALDH1A1 (0.50) | TSHRJAK2ERCC5FEN1ALDH1A1 | |
| SCHEMBL29952517 | 0.73 | CES2 (0.60) | TSHRERCC5FEN1ALDH1A1CYP1A2 | |
| SCHEMBL293634 | 0.73 | CES2 (0.60) | TSHRERCC5FEN1ALDH1A1CYP1A2 | |
| SCHEMBL5272752 | 0.71 | TSHR (0.58) | TSHRCXCL12JAK2TAS1R3TAS1R1 | |
| SCHEMBL5272753 | 0.71 | TSHR (0.58) | TSHRCXCL12JAK2TAS1R3TAS1R1 | |
| Water SCHEMBL10353121 | 0.71 | CES2 (0.58) | TSHRERCC5FEN1ALDH1A1CYP1A2 | |
| SCHEMBL9178892 | 0.71 | MAPK1 (0.39) | TSHRALDH1A1CES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0800520-B1 | PROCESS FOR THE PREPARATION OF LAMOTRIGINE | WELLCOME FOUND (GB) | 2002-06-19 | — | — | EP | disclosed |
| US-5912345-A | CHEMICAL CONDENSATION WITH CYCLIZATION AFTER TREATMENT WITH ULTRAVIOLET OR VISIBLE RADIATION | GLAXO WELLCOME INC. (US) | 1999-06-15 | — | — | US | disclosed |
| EP-0800520-A1 | PROCESS FOR THE PREPARATION OF LAMOTRIGINE | THE WELLCOME FOUNDATION LIMITED (GB) | 1997-10-15 | — | — | EP | disclosed |
| WO-1996020934-A1 | PROCESS FOR THE PREPARATION OF LAMOTRIGINE | THE WELLCOME FOUNDATION LIMITED (GB) | 1996-07-11 | — | — | WO | disclosed |