Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 3/20 | 0.42 |
| ▸ | MMP9 | P14780 | 3/20 | 0.42 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.41 |
| ▸ | PFKFB4 | Q16877 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 5/20 | 0.41 |
| ▸ | CA1 | P00915 | 5/20 | 0.41 |
| ▸ | CA2 | P00918 | 5/20 | 0.41 |
| ▸ | CA9 | Q16790 | 5/20 | 0.41 |
| ▸ | HSD17B1 | P14061 | 3/20 | 0.41 |
| ▸ | HSD17B2 | P37059 | 3/20 | 0.41 |
| ▸ | ESRRG | P62508 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3254332 | 1.00 | MMP2 (0.42) | MMP2MMP9PFKFB3PFKFB4CA12 | |
| SCHEMBL14569173 | 0.83 | PTGS2 (0.43) | MMP2MMP9PFKFB3PFKFB4CA12 | |
| SCHEMBL2764152 | 0.83 | IKBKB (0.47) | MMP2MMP9CA12CA1CA2 | |
| SCHEMBL7336143 | 0.83 | HSD17B1 (0.45) | PFKFB3PFKFB4CA12CA1CA2 | |
| SCHEMBL6970542 | 0.83 | HSD17B1 (0.45) | PFKFB3PFKFB4CA12CA1CA2 | |
| SCHEMBL7057540 | 0.81 | KDM4E (0.42) | MMP2MMP9CA12CA1CA2 | |
| SCHEMBL13743183 | 0.81 | CA2 (0.56) | MMP2MMP9PFKFB3PFKFB4CA12 | |
| SCHEMBL7056144 | 0.81 | MEN1 (0.49) | PFKFB3CA12CA1CA2CA9 | |
| SCHEMBL7341689 | 0.81 | CA12 (0.44) | PFKFB3CA12CA1CA2CA9 | |
| SCHEMBL957340 | 0.81 | CA12 (0.44) | PFKFB3CA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0980369-A1 | SULFONAMIDES FOR TREATMENT OF ENDOTHELIN-MEDIATED DISORDERS | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2000-02-23 | — | — | EP | disclosed |
| WO-1998049162-A1 | SULFONAMIDES FOR TREATMENT OF ENDOTHELIN-MEDIATED DISORDERS | TEXAS BIOTECHNOLOGY CORPORATION (US) | 1998-11-05 | — | — | WO | disclosed |