Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | SLC13A5 | Q86YT5 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CDC7 | O00311 | 1/20 | 0.33 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7542788 | 0.89 | SLC13A5 (0.35) | ALDH1A1KDM4EGLANPC1MAPT | |
| SCHEMBL7542068 | 0.89 | ALOX5 (0.39) | ALOX5ALDH1A1SOAT1KDM4EGLA | |
| SCHEMBL7543546 | 0.84 | ALOX15 (0.35) | ALDH1A1KDM4EGLACYP1A2MAPT | |
| SCHEMBL7541370 | 0.75 | ALDH1A1 (0.44) | ALDH1A1KDM4ECYP1A2NPC1MAPT | |
| SCHEMBL7547389 | 0.73 | KDM4E (0.41) | ALDH1A1KDM4ECYP1A2NPC1MAPT | |
| SCHEMBL7540966 | 0.73 | CCR4 (0.36) | ALDH1A1KDM4ECYP1A2MAPTSLC13A5 | |
| SCHEMBL16852121 | 0.72 | ALDH1A1 (0.39) | ALOX5ALDH1A1SOAT1KDM4ECYP1A2 | |
| SCHEMBL7542145 | 0.72 | PARP10 (0.39) | ALDH1A1KDM4ECYP1A2MAPTSMN1; SMN2 | |
| SCHEMBL28695215 | 0.71 | GRM5 (0.36) | ALDH1A1NPC1MAPTKMT2AL3MBTL1 | |
| SCHEMBL12409948 | 0.71 | GRM5 (0.36) | ALDH1A1KDM4ENPC1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0889038-B1 | Process for the preparation of alkoxy-or aryloxypyrazine derivatives | LONZA AG (CH) | 2002-05-29 | — | — | EP | claimed |
| EP-0889038-A1 | Process for the preparation of alkoxy-or aryloxypyrazine derivatives | LONZA AG (CH) | 1999-01-07 | — | — | EP | claimed |
| EP-0889038-B1 | Process for the preparation of alkoxy-or aryloxypyrazine derivatives | LONZA AG (CH) | 2002-05-29 | — | — | EP | disclosed |
| EP-0889038-A1 | Process for the preparation of alkoxy-or aryloxypyrazine derivatives | LONZA AG (CH) | 1999-01-07 | — | — | EP | disclosed |