Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR4 | P51679 | 2/20 | 0.36 |
| ▸ | EDNRA | P25101 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | SLC13A5 | Q86YT5 | 2/20 | 0.33 |
| ▸ | SLC13A2 | Q13183 | 1/20 | 0.33 |
| ▸ | SLC13A3 | Q8WWT9 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.32 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.32 |
| ▸ | HPGDS | O60760 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7542788 | 0.85 | SLC13A5 (0.35) | ALDH1A1KDM4EMAPTSLC13A5POLB | |
| SCHEMBL7542068 | 0.85 | ALOX5 (0.39) | ALDH1A1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL7544018 | 0.83 | POLB (0.38) | CCR4EDNRAALDH1A1HPGDSPOLB | |
| SCHEMBL15233567 | 0.79 | CCR4 (0.38) | CCR4EDNRAALDH1A1KDM4EHPGD | |
| SCHEMBL7541379 | 0.74 | NPSR1 (0.47) | CCR4EDNRAALDH1A1KDM4EHPGD | |
| SCHEMBL1475724 | 0.74 | NPSR1 (0.47) | CCR4ALDH1A1KDM4EHPGDMEN1 | |
| SCHEMBL7549980 | 0.73 | ALOX5 (0.39) | ALDH1A1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL6642410 | 0.72 | CCR4 (0.45) | CCR4EDNRAALDH1A1MEN1KMT2A | |
| SCHEMBL7542243 | 0.71 | POLB (0.40) | CCR4EDNRAALDH1A1KDM4EHPGD | |
| SCHEMBL3170311 | 0.70 | POLB (0.42) | CCR4EDNRAHPGDSPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0889038-B1 | Process for the preparation of alkoxy-or aryloxypyrazine derivatives | LONZA AG (CH) | 2002-05-29 | — | — | EP | claimed |
| EP-0889038-A1 | Process for the preparation of alkoxy-or aryloxypyrazine derivatives | LONZA AG (CH) | 1999-01-07 | — | — | EP | claimed |
| EP-0889038-B1 | Process for the preparation of alkoxy-or aryloxypyrazine derivatives | LONZA AG (CH) | 2002-05-29 | — | — | EP | disclosed |
| EP-0889038-A1 | Process for the preparation of alkoxy-or aryloxypyrazine derivatives | LONZA AG (CH) | 1999-01-07 | — | — | EP | disclosed |