Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 2/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.33 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7550283 | 1.00 | CHRNB2 (0.43) | CHRNB2CHRNA4ALDH1A1POLBNR1H4 | |
| SCHEMBL7546223 | 0.84 | CHRNB2 (0.54) | CHRNB2CHRNA4ALDH1A1NR1H4HDAC4 | |
| SCHEMBL7546225 | 0.84 | CHRNB2 (0.54) | CHRNB2CHRNA4ALDH1A1NR1H4HDAC4 | |
| SCHEMBL7548331 | 0.76 | ALDH1A1 (0.41) | CHRNB2CHRNA4ALDH1A1POLBLMNA | |
| SCHEMBL7548332 | 0.76 | ALDH1A1 (0.41) | CHRNB2CHRNA4ALDH1A1POLBLMNA | |
| SCHEMBL7545910 | 0.69 | ALDH1A1 (0.41) | ALDH1A1NR1H4HDAC4MAPTMAPK1 | |
| SCHEMBL7545918 | 0.69 | ALDH1A1 (0.41) | ALDH1A1NR1H4HDAC4MAPTMAPK1 | |
| SCHEMBL6255110 | 0.66 | CHRNB2 (0.56) | CHRNB2CHRNA4MAPTGFER | |
| SCHEMBL6253108 | 0.66 | CHRNB2 (0.56) | CHRNB2CHRNA4MAPTGFER | |
| SCHEMBL6253103 | 0.66 | CHRNB2 (0.56) | CHRNB2CHRNA4MAPTGFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1214288-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE | Targacept Inc. (US) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001017943-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE | TARGACEPT, INC. (US) | 2001-03-15 | — | — | WO | disclosed |