Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.39 |
| ▸ | CES2 | O00748 | 4/20 | 0.37 |
| ▸ | CES1 | P23141 | 4/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | RBBP9 | O75884 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7642306 | 0.74 | ALOX5 (0.49) | ALOX5CYP1A2CYP2D6L3MBTL1 | |
| SCHEMBL7087828 | 0.71 | SMN1; SMN2 (0.37) | CES2CES1CA1CA2SLC6A2 | |
| SCHEMBL11468486 | 0.70 | ALOX5 (0.45) | ALOX5CYP1A2CYP2C19KDM4E | |
| SCHEMBL15680018 | 0.70 | CES2 (0.63) | CES2CES1CA1CA2KDM4E | |
| SCHEMBL5444935 | 0.70 | CES2 (0.63) | CES2CES1CA1CA2KDM4E | |
| SCHEMBL29077329 | 0.68 | CES2 (0.52) | CES2CES1CA1CA2SLC6A2 | |
| SCHEMBL4869727 | 0.68 | CES2 (0.52) | CES2CES1CA1CA2SLC6A2 | |
| SCHEMBL835861 | 0.67 | CES2 (0.56) | CES2CES1CA1CA2SLC6A2 | |
| SCHEMBL9588015 | 0.67 | ALOX5 (0.35) | ALOX5SLC6A3CYP2C19KDM4E | |
| SCHEMBL7087822 | 0.67 | CES2 (0.50) | ALOX5CES2CES1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0699192-B1 | SUBSTITUTED OXAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | SEARLE & CO (US) | 2002-07-24 | — | — | EP | disclosed |
| US-6090834-A | ANALGESICS; RHEUMATIC DISORDERS; SKIN DISORDERS; GASTROINTESTINAL DISORDERS | G.D. SEARLE & CO. (US) | 2000-07-18 | — | — | US | disclosed |
| WO-1996036617-A1 | SUBSTITUTED OXAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-11-21 | — | — | WO | disclosed |