Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 7/20 | 0.36 |
| ▸ | TP53 | P04637 | 6/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 4/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.33 |
| ▸ | RELA | Q04206 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | PRKCA | P17252 | 1/20 | 0.32 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7556779 | 0.99 | LMNA (0.35) | LMNATP53KMT2AKDM4EALDH1A1 | |
| SCHEMBL7550697 | 0.79 | MEN1 (0.31) | KMT2AMEN1BRD4 | |
| SCHEMBL7550700 | 0.79 | NOS1 (0.49) | — | |
| Hydrochloric Acid SCHEMBL7556788 | 0.78 | NOS1 (0.50) | — | |
| SCHEMBL7549919 | 0.76 | MAPT (0.39) | LMNATP53KMT2AALDH1A1PKM | |
| Hydrochloric Acid SCHEMBL7552145 | 0.75 | MAPT (0.38) | LMNATP53KMT2AALDH1A1PKM | |
| SCHEMBL7506573 | 0.74 | PNMT (0.46) | LMNAMAPTNPC1NFKB1RAB9A | |
| Hydrochloric Acid SCHEMBL7506643 | 0.73 | PNMT (0.45) | LMNAMAPTNPC1NFKB1RAB9A | |
| SCHEMBL7511436 | 0.71 | MAPT (0.39) | LMNAKMT2AMAPTMEN1NPC1 | |
| Hydrochloric Acid SCHEMBL7510690 | 0.71 | MAPT (0.38) | LMNAKMT2AMAPTMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0861250-B1 | AMIDINE AND ISOTHIOUREA DERIVATIVES AS INHIBITORS OF NITRIC OXIDE SYNTHASE | ASTRAZENECA AB (SE) | 2002-02-13 | — | — | EP | claimed |
| US-6140322-A | Amidine and isothiourea derivatives as inhibitors of nitric oxide synthase | ASTRA AKTIEBOLAG (SE) | 2000-10-31 | — | — | US | claimed |