Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 4/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13789607 | 0.89 | KMT2A (0.60) | HTTHSD11B1MEN1KMT2AKDM4E | |
| SCHEMBL733606 | 0.84 | HSD11B1 (0.64) | HTTHSD11B1MEN1KMT2AKDM4E | |
| SCHEMBL7124208 | 0.83 | LMNA (0.67) | HTTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL733434 | 0.81 | KMT2A (0.52) | HTTHSD11B1ALDH1A1MEN1KMT2A | |
| SCHEMBL12550418 | 0.81 | LMNA (0.67) | HSD11B1ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL735124 | 0.80 | LMNA (0.66) | HTTHSD11B1ALDH1A1MEN1KMT2A | |
| SCHEMBL734562 | 0.80 | HSD11B1 (0.58) | HTTHSD11B1MEN1KMT2AKDM4E | |
| SCHEMBL751828 | 0.78 | ALDH1A1 (0.66) | HTTHSD11B1ALDH1A1MEN1KMT2A | |
| SCHEMBL735495 | 0.78 | GAA (0.69) | HSD11B1ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL4402433 | 0.78 | LMNA (0.90) | HTTHSD11B1ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138190-B2 | Diaza heterocyclic amide compounds and their uses | AMGEN INC. (US) | 2012-03-20 | — | — | US | disclosed |