SCHEMBL7552092

SCHEMBL7552092

COc1cccc2c1[nH]c(=O)n2C(=O)Oc1ccccc1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DAO P14920 2/20 0.57
ALDH1A1 P00352 6/20 0.43
TSHR P16473 4/20 0.43
GAA P10253 4/20 0.43
MAPT P10636 3/20 0.43
KDM4E B2RXH2 3/20 0.43
HPGD P15428 3/20 0.43
KMT2A Q03164 2/20 0.43
POLB P06746 2/20 0.43
HTT P42858 2/20 0.43
SMN1; SMN2 Q16637 2/20 0.43
MEN1 O00255 1/20 0.43
RECQL P46063 1/20 0.43
MCL1 Q07820 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
PKM P14618 1/20 0.41
MAPK1 P28482 1/20 0.41
CYP3A4 P08684 2/20 0.38
CYP2D6 P10635 1/20 0.38
OGT O15294 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7058467 0.76 DAO (0.49) DAOALDH1A1TSHRGAAMAPT
SCHEMBL7477638 0.72 DAO (0.61) DAOALDH1A1TSHRGAAMAPT
SCHEMBL194512 0.71 DAO (0.69) DAOALDH1A1TSHRGAAMAPT
SCHEMBL9118532 0.70 DAO (0.61) DAOALDH1A1TSHRGAAMAPT
SCHEMBL12792523 0.68 DAO (0.63) DAOALDH1A1TSHRGAAMAPT
SCHEMBL14906566 0.68 DAO (0.45) DAOALDH1A1TSHRGAAMAPT
SCHEMBL28512474 0.67 DAO (0.53) DAOKMT2A
SCHEMBL28512471 0.67 DAO (0.53) DAOKMT2A
SCHEMBL17502696 0.65 CA2 (0.60) MAPTKDM4EHPGDKMT2APOLB
SCHEMBL1135497 0.63 DAO (0.56) DAOALDH1A1TSHRGAAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1218352-A1 BENZIMIDAZOLONE DERIVATIVES HAVING MIXED SEROTONINE AND DOPAMINE RECEPTORS AFFINITY BOEHRINGER INGELHEIM ITALIA S.p.A. (IT) 2002-07-03 EP disclosed
US-6281218-B1 USEFUL IN THE TREATMENT OF CNS DISORDERS. INGELHEIM ITALIA S.P.A. (IT) 2001-08-28 US disclosed
WO-2001021593-A1 NEW BENZIMIDAZOLONE DERIVATIVES HAVING MIXED SEROTONINE AND DOPAMINE RECEPTORS AFFINITY BOEHRINGER INGELHEIM ITALIA S.P.A. (IT) 2001-03-29 WO disclosed