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SCHEMBL7554403

SCHEMBL7554403

COC(=O)c1c2c3c(cc(Cl)cc3n1S(=O)(=O)c1ccccc1)CCC2C(C)C(=O)Nc1ccc(NC(=O)OC(C)(C)C)cc1OCC(=O)OC(C)(C)C

nearest known ligand 0.34

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ RORC P51449 15/20 0.34
▸ ACLY P53396 1/20 0.33
▸ NR1I3 Q14994 1/20 0.32
▸ MMP8 P22894 3/20 0.32
▸ MMP3 P08254 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7551110 0.90 RORC (0.36) RORCMMP8MMP3
SCHEMBL7547397 0.80 CNR1 (0.32) NR1I3
SCHEMBL7549335 0.78 MAPK8 (0.35) —
SCHEMBL7549039 0.77 ALOX15 (0.32) NR1I3
SCHEMBL7549297 0.74 MAPK8 (0.36) —
SCHEMBL7550091 0.74 NR1I3 (0.32) RORCNR1I3
SCHEMBL7551106 0.70 NAMPT (0.31) RORCACLY
SCHEMBL7549547 0.70 PPARD (0.35) —
SCHEMBL7548899 0.70 GRIN2D (0.40) RORC
SCHEMBL7548644 0.69 MAPK14 (0.32) NR1I3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0657427-B1 Tricyclic indole-2-carboxylic acid derivatives being selective antagonists of the NMDA receptor SUMITOMO PHARMA (JP) 2002-06-19 — — EP disclosed
US-5496843-A Tricyclic indole-2-carboxylic acid derivatives SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) 1996-03-05 — — US disclosed
EP-0657427-A1 Tricyclic indole-2-carboxylic acid derivatives being selective antagonists of the NMDA receptor SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) 1995-06-14 — — EP disclosed