Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | DHODH | Q02127 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | APAF1 | O14727 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7517108 | 0.83 | MEN1 (0.38) | ALDH1A1MEN1KMT2APOLBDHODH | |
| SCHEMBL7525033 | 0.82 | RAB9A (0.56) | ALDH1A1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL7558368 | 0.80 | P2RX3 (0.38) | MEN1KMT2AMAPTPOLBDHODH | |
| SCHEMBL7560746 | 0.78 | KDM4E (0.46) | RAPGEF4ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL7524238 | 0.73 | RAPGEF4 (0.46) | RAPGEF4ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL9513146 | 0.71 | RAPGEF4 (0.68) | RAPGEF4ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL7518438 | 0.69 | EPHX1 (0.61) | ALDH1A1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL7522460 | 0.66 | MAPT (0.42) | ALDH1A1MEN1KMT2AMAPTHTT | |
| SCHEMBL28736208 | 0.66 | MAPT (0.59) | RAPGEF4ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL29633284 | 0.66 | MAPT (0.59) | RAPGEF4ALDH1A1MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1173420-A2 | HETEROCYCLIC COMPOUNDS HAVING ANTITUMOR ACTIVITY | Novuspharma S.p.A. (IT) | 2002-01-23 | — | — | EP | disclosed |
| WO-2000053581-A2 | HETEROCYCLIC COMPOUNDS HAVING ANTITUMOR ACTIVITY | NOVUSPHARMA S.P.A. (IT) | 2000-09-14 | — | — | WO | disclosed |