Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | GPBAR1 | Q8TDU6 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.35 |
| ▸ | GNRHR | P30968 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7818937 | 0.87 | PTGS2 (0.44) | PTGS2POLBGPBAR1KMT2AMEN1 | |
| SCHEMBL7563981 | 0.81 | GPBAR1 (0.40) | PTGS2POLBGPBAR1KMT2AMEN1 | |
| SCHEMBL7558468 | 0.78 | GPBAR1 (0.38) | PTGS2POLBGPBAR1KMT2AMEN1 | |
| SCHEMBL7557817 | 0.78 | GPBAR1 (0.40) | PTGS2GPBAR1 | |
| SCHEMBL6202118 | 0.75 | MEN1 (0.43) | PTGS2POLBKMT2AMEN1TDP1 | |
| SCHEMBL5165927 | 0.75 | MAP3K5 (0.38) | PTGS2KMT2AMEN1MAPTSMN1; SMN2 | |
| SCHEMBL7565085 | 0.74 | KDM4E (0.40) | PTGS2POLBKMT2AMEN1MAPT | |
| SCHEMBL7557482 | 0.74 | PTGS2 (0.36) | PTGS2POLBKMT2AMEN1MAPT | |
| SCHEMBL7862448 | 0.73 | KMT2A (0.38) | PTGS2POLBGPBAR1KMT2AMEN1 | |
| SCHEMBL40302 | 0.73 | MEN1 (0.45) | POLBKMT2AMEN1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1224172-A1 | DRUGS FOR THE TREATMENT OF MALIGNANT TUMOURS | Active Biotech AB (SE) | 2002-07-24 | — | — | EP | disclosed |
| WO-2001030758-A1 | DRUGS FOR THE TREATMENT OF MALIGNANT TUMOURS | ACTIVE BIOTECH AB (SE) | 2001-05-03 | — | — | WO | disclosed |