Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | PLAU | P00749 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7557482 | 0.86 | PTGS2 (0.36) | KDM4EALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL7565042 | 0.82 | ALOX5 (0.36) | KDM4EALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL7560716 | 0.82 | KDM4E (0.49) | KDM4EALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL11291425 | 0.76 | KDM4E (0.48) | KDM4EALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL6204567 | 0.76 | HDAC4 (0.49) | ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL7556725 | 0.75 | KMT2A (0.43) | KDM4EALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL7818937 | 0.75 | PTGS2 (0.44) | ALDH1A1SMN1; SMN2KMT2AMEN1HPGD | |
| SCHEMBL7829055 | 0.74 | PTGS2 (0.40) | KMT2AMEN1PTGS2TSHRPGR | |
| SCHEMBL7828560 | 0.74 | GPBAR1 (0.40) | KDM4ESMN1; SMN2KMT2AMEN1 | |
| SCHEMBL7555419 | 0.74 | PTGS2 (0.46) | KDM4EALDH1A1SMN1; SMN2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1224172-A1 | DRUGS FOR THE TREATMENT OF MALIGNANT TUMOURS | Active Biotech AB (SE) | 2002-07-24 | — | — | EP | claimed |
| WO-2001030758-A1 | DRUGS FOR THE TREATMENT OF MALIGNANT TUMOURS | ACTIVE BIOTECH AB (SE) | 2001-05-03 | — | — | WO | claimed |