Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | GABRP | O00591 | 1/20 | 0.33 |
| ▸ | GABRD | O14764 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7555698 | 0.79 | HDAC8 (0.46) | HDAC8KDM4EMAPT | |
| SCHEMBL28038780 | 0.78 | GAA (0.54) | HDAC8BRD4CREBBPMAPTGABRP | |
| SCHEMBL8562595 | 0.78 | GAA (0.54) | HDAC8BRD4CREBBPMAPTGABRP | |
| SCHEMBL924219 | 0.78 | GAA (0.54) | HDAC8BRD4CREBBPMAPTGABRP | |
| SCHEMBL30288898 | 0.78 | GAA (0.54) | HDAC8BRD4CREBBPMAPTGABRP | |
| SCHEMBL29463686 | 0.78 | GAA (0.54) | HDAC8BRD4CREBBPMAPTGABRP | |
| SCHEMBL28114454 | 0.77 | GAA (0.53) | HDAC8BRD4CREBBPMAPT | |
| SCHEMBL9370418 | 0.75 | DRD2 (0.46) | DRD2DRD4ESR2 | |
| SCHEMBL29012624 | 0.75 | GABRP (0.38) | CHRNB2CHRNA4KDM4EMAPTGABRP | |
| SCHEMBL13202969 | 0.73 | GAA (0.62) | DRD2DRD4ESR2ESR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0823425-B1 | Process for the preparation of an enantiopure tetrahydroquinoline-carboxylic acid | ARCHIMICA SPA (IT) | 2000-10-18 | — | — | EP | disclosed |
| US-5905155-A | Process for the preparation of an optically pure tetrahydroquinoline carboxylic acid | ARCHIMICA SPA (IT) | 1999-05-18 | — | — | US | disclosed |
| EP-0823425-A1 | Process for the preparation of an optically pure tetrahydroquinoline-carboxylic acid | Archimica S.p.A. (IT) | 1998-02-11 | — | — | EP | disclosed |